Phoenix dactylifera (Ajwa Date) Whole Fruit, Flesh and Powdered Seed Prevents Anti-Tuberculous Drug Induced Hepatotoxicity in Rabbits

Sadia Majeed
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引用次数: 1

Abstract

Introduction: Hepatotoxicity induced by anti-tuberculous medicine is known due to their oxidative stress. Ajwa dates may have a role to protect liver from oxidative stress Aims & Objectives: To assess the preventive effect of Ajwa date on hepatotoxicity induced by anti-tuberculous drugs in rabbits. Place and duration of study: Post Graduate Medical Institute, Lahore for three months, from May 2014 to July 2014. Material & Methods: Thirty rabbits were distributed into five groups. Rabbits of Group A and of B were fed on normal diet in form of pellets. Group C, D and E were provided diet containing one whole Ajwa date, flesh of one Ajwa date and powdered seed of one Ajwa date respectively in each 100 grams of diet throughout study. Group B, C, D and E were administered 50mg/kg isoniazid and 100mg/kg rifampicin orally for 14 days. Serum levels of liver enzymes Alanine transaminase (ALT), Aspartate transaminase (AST) and Alkaline phosphatase (ALP) and bilirubin were estimated on day 0 and 14. One way ANOVA followed by post hoc Tukey’s test and t-test were applied for statistical analysis using SPSS 20. Results: Baseline LFTs were normal in all groups. Significant hepatotoxicity was observed after 2weeks of INH and rifampicin administration in disease control group B (ALT 200.2±19.3 & ALP 231.0±21.3 IU/L, AST 139.0±22 & bilirubin 0.48±0.046mg/dl, (p value < 0.001) as compared to healthy control group A (ALT47.2 ± 6.7 & ALP78.2 ±5.0 IU/L, AST 43.0 ± 9.7, bilirubin 0.10± 0.00mg/dl). (p value < 0.001). Concomitant Ajwa intake during the same period resulted in an equipotent significantly similar improvement in LFTs in Groups C (whole date) ALT55.7 ± 4.7&ALP 91.5 ±5.0IU/L, AST, 59.0 ± 15.3 &bilirubin 0.09 ±0.02 mg/dl): D (flesh) ALT89.8 ± 6.3 & ALP111.3 ±9.4 IU/L, AST73.7 ± 8.3 & bilirubin0.12± 0.04 mg/dl & E (seed powder) ALT85.8 ± 8.6 IU/L &ALP 92.8 ±11.4 IU/L, AST57.5 ± 5.3 & bilirubin 0.12 ±0.04 mg/dl) versus group B (p value < 0.001). and near normalization of liver function close to that of healthy control group Conclusion: Co-administration of Ajwa date whole fruit, flesh and seed powder are equipotent and effective in preventing isoniazid and rifampicin induced hepatotoxicity.
黄枣全果、果肉及种子粉对抗结核药物致兔肝毒性的影响
简介:抗结核药物引起的肝毒性是由其氧化应激引起的。目的:探讨荷花枣对抗结核药物致兔肝毒性的预防作用。学习地点和时间:2014年5月至2014年7月,在拉合尔研究生医学研究所学习三个月。材料与方法:30只家兔随机分为5组。A组和B组以颗粒形式饲喂正常饲粮。C组、D组和E组在整个研究过程中,每100 g饲粮中分别添加1个全秋枣、1个秋枣果肉和1个秋枣籽粉。B、C、D、E组分别给予异烟肼50mg/kg和利福平100mg/kg,口服14 D。测定第0、14天血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)和胆红素水平。采用单因素方差分析、事后Tukey检验和t检验,采用SPSS 20进行统计分析。结果:各组基线LFTs均正常。疾病对照组B组(ALT为200.2±19.3,ALP为231.0±21.3 IU/L, AST为139.0±22,胆红素为0.48±0.046mg/dl)与健康对照组A组(ALT为47.2±6.7,alp为78.2±5.0 IU/L, AST为43.0±9.7,胆红素为0.10±0.00mg/dl)相比,给予INH和利福平治疗2周后肝毒性显著(p值< 0.001)。(p值< 0.001)。与B组相比,C组(全枣)ALT55.7±4.7&ALP 91.5±5.0IU/L, AST 59.0±15.3 &胆红素0.09±0.02 mg/dl; D组(果肉)ALT89.8±6.3 & ALP111.3±9.4 IU/L, AST73.7±8.3 &胆红素0.12±0.04 mg/dl; E组(种子粉)ALT85.8±8.6 IU/L & alp 92.8±11.4 IU/L, AST57.5±5.3 &胆红素0.12±0.04 mg/dl)的LFTs有相同的显著改善(p值< 0.001)。结论:红枣全果、果肉、籽粉同服对异烟肼和利福平所致的肝毒性具有同等预防作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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