Hepatoprotective Activity of Ethanolic Extract of the Stems of Anisochilus Carnosus against Carbon Tetrachloride-induced Hepatotoxicity in Rats

International journal of health research and innovation Pub Date : 2011-10-05 DOI:10.4314/IJHR.V3I3.70303

P. Venkatesh, A. Dinakar, N. Senthilkumar

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引用次数: 20

Abstract

Purpose: To evaluate the hepatoprotective activity of ethanolic extract of the stems of Anisochilus Carnosus (EEAC) against carbon tetrachloride (CCl 4 ) induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced in albino Wistar rats of either sex by intraperitoneal injection of CCl 4 in olive oil (1:1). Two doses of ethanolic extract of Anisochilus Carnosus (200 and 400 mg/kg body weight) were administered to the experimental rats. The hepatoprotective effect of the extract was evaluated by the assay of liver function biochemical parameters like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, total bilirubin and total protein. Results: In ethanolic extract treated animals, the toxic effect of CCl 4 was significantly controlled by the plant extract as compared to the normal and the standard drug silymarin treated group. Conclusion: Ethanolic extract of stems of Anisochilus Carnosus possesses significant hepatoprotective activity. Keywords: Anisochilus carnosus, Hepatoprotective activity, Hepatotoxicity, Carbon tetrachloride, Silymarin.

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山楂茎醇提物对四氯化碳致大鼠肝毒性的保护作用

目的:研究山楂茎醇提物(EEAC)对四氯化碳(ccl4)致大鼠肝毒性的保护作用。方法:采用橄榄油中氯化氯化钠(1:1)腹腔注射法，对白化Wistar大鼠进行肝毒性实验。实验大鼠分别给予山楂乙醇提取物200和400 mg/kg体重。通过血清谷氨酸丙酮酸转氨酶、谷氨酸草酰乙酸转氨酶、碱性磷酸酶、总胆红素、总蛋白等肝功能生化指标的测定，评价提取物的保肝作用。结果:与水飞蓟素对照组和标准药物组相比，乙醇提取物对动物ccl4的毒性作用得到了明显的控制。结论:山楂茎醇提物具有明显的保肝作用。关键词:山楂，保肝活性，肝毒性，四氯化碳，水飞蓟素

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International journal of health research and innovation

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