Natural nutraceuticals - do we know what we are using?

J. Hudeček, A. Michalíková, P. Hodek
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Abstract

In the current „industrial“ world, the „natural“ nutraceuticals of plant origin are increasingly popular as dietary supplements, herbal remedies or fitness enhancers, preferred by many in comparison with the „chemical drugs“, produced by the pharmaceutical industry. Alas, one well-known disadvantage of the drugs and extracts based on natural products is their potential variability, which may make any of their effects irreproducible or unreliable. We demonstrate this variability on the preparations based on the sea-buckthorn (Hippopae rhamnoides), which is a rather popular source of unsatorated fatty acids, rich in vitamins, containing also a plethora of polyphenolics and other potentially biologically active coumpounds. Analytical data from literature and from various commercially available preparates of „oil from berries“ were compared. Both the macroscopic parameters of the preparations, and the details of their composition vary rather widely, reflecting not only biological (and geographic) variablity of the species, but possibly also the influence of the used extraction method and of the final adjustment in the commercial preparate. This variablity is reflected also in the differing stability during storage and it may quite strongly influence the potential biological effects and benefits connected with the use ot the sea-buckthorn-based nutraceuticals.
天然营养保健品-我们知道我们在使用什么吗?
在当前的“工业”世界中,植物来源的“天然”营养保健品作为膳食补充剂、草药或健身增强剂越来越受欢迎,与制药工业生产的“化学药物”相比,许多人更喜欢它们。唉,以天然产品为基础的药物和提取物的一个众所周知的缺点是它们潜在的可变性,这可能使它们的任何效果不可复制或不可靠。我们在沙棘(Hippopae rhamnoides)的基础上证明了这种差异性,沙棘是一种相当受欢迎的不饱和脂肪酸来源,富含维生素,还含有大量的多酚类物质和其他潜在的生物活性化合物。从文献和从各种市售的“浆果油”制备的分析数据进行了比较。制剂的宏观参数及其组成的细节变化相当大,不仅反映了物种的生物(和地理)可变性,而且可能还反映了所使用的提取方法和商业制剂中最终调整的影响。这种多样性也反映在储存期间的不同稳定性上,它可能会非常强烈地影响与使用沙棘营养保健品有关的潜在生物效应和益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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