CRYSTAL STRUCTURES OF 2-FURYLBENZIMIDAZOLES WITH ANTIANGIOGENIC INHIBITION OF VEGF IN CELL LINE MCF-7

Abstract

The first crystal structures of four 2-furylbenzimidazole acetohydrazide derivatives are reported herein. The compounds have been shown to be planar with a small cant that varies from 4 to 30°. The X-ray crystal structure of the compounds 7-10 revealed that compounds are oriented in the cis configuration which suggests that the acid hydrazide group is essential for the enhanced potency of 2-furylbenzimidazoles as anti-angiogenic agents.