Molecular diagnosis of tuberculosis with emphasis on Xpert Mycobacterium tuberculosis assay – Clinical review

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
G. Gaude, S. Vishwanath
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引用次数: 1

Abstract

Tuberculosis (TB), due to Mycobacterium tuberculosis(MTB), remains a major public health issue. It causes ill health for approximately 10 million people each year and is one of the top ten causes of death worldwide. For the past 5 years, it has been the leading cause of death from a single infectious agent, ranking above HIV/AIDS. Effective diagnosis of pulmonary TB requires the availability – on a global scale – of standardized, easy-to-use, and robust diagnostic tool that would allow the direct detection of both the MTB complex and the resistance to key drugs, such as rifampicin. The latter result can serve as a marker for multidrug-resistant (MDR) MTB and has been reported in >95% of the MDR-TB isolates. Here, we review some of the recent molecular methods in the diagnosis of TB.
以Xpert结核分枝杆菌检测为重点的结核病分子诊断-临床综述
由结核分枝杆菌(MTB)引起的结核病(TB)仍然是一个主要的公共卫生问题。它每年造成大约1 000万人健康不良,是全世界十大死亡原因之一。在过去5年里,它一直是导致死亡的单一传染病的主要原因,超过艾滋病毒/艾滋病。有效诊断肺结核需要在全球范围内提供标准化、易于使用和强大的诊断工具,从而能够直接检测结核分枝杆菌复合体和对利福平等关键药物的耐药性。后一种结果可作为耐多药(MDR) MTB的标记物,并已在95%的MDR- tb分离株中报告。在这里,我们回顾了一些最近的分子方法在结核病的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Sciences
Journal of Clinical Sciences MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
15
审稿时长
45 weeks
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