High sensitive detections of Norovirus DNA and IgG by using multi-SiNW-FET biosensors

Abstract

This paper reports ultrasensitive detections of DNA and protein by multi-silicon-nanowire field-effect-transistor (SiNW-FET) biosensors. Single-SiNW-FET, double-SiNW-FET and quad-SiNW-FET have been designed on a single chip and fabricated by a simple top-down fabrication process. Compared with single-SiNW-FET, the multi-SiNW-FET biosensor shows a higher ability of decreasing the noise by averaging the source-drain currents. Both Norovirus DNA and IgG have been detected with the sensors at concentrations as low as 1 fM and 10 fM respectively. The sensor also shown high specificity in 1bp mismatch DNA disturbance.