Metastatic involvement and perforation of the appendix in a patient with parotid gland tumor treated with paclitaxel

T. Grenader, Anthony Goldberg, C. Reinus
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Abstract

Salivary duct carcinoma is an uncommon malignant tumor, characterized by aggressive behavior and poor prognosis. It accounts for approximately 1–3% of all malignant salivary gland tumors (2), and it is found mainly in the parotid gland, followed by the other major salivary glands (2). Histologically, salivary duct carcinoma resembles ductal carcinoma of the breast (3). Immunohistochemically, the tumor cells are positive for keratin and epithelial membrane antigen. Stains for gross cystic disease fluid protein-15 (GCDFP-15) and androgen receptor are frequently positive, but only rare expression of estrogen and progesterone receptors has been described (3). Metastases are a common feature in the evolution of parotid gland cancer. Gastrointestinal metastases, however, and especially appendicular ones, are very rare. The intrinsic nature of malignant metastases in the appendix leads to a late presentation of appendicitis with a high incidence of perforation, associated with an increased mortality and morbidity (1). We describe the case of a patient presenting as an acute abdomen because of metastatic involvement with perforation of the vermiform appendix from a salivary duct carcinoma of the parotid gland treated with paclitaxel.
经紫杉醇治疗的腮腺肿瘤患者阑尾转移及穿孔
摘要唾液管癌是一种罕见的恶性肿瘤,具有侵袭性和预后差的特点。约占所有恶性唾液腺肿瘤的1-3%(2),主要发生在腮腺,其次是其他主要唾液腺(2)。组织学上,唾液腺导管癌类似于乳腺导管癌(3)。免疫组织化学上,肿瘤细胞角蛋白和上皮膜抗原阳性。总囊性疾病液蛋白-15 (GCDFP-15)和雄激素受体的染色通常呈阳性,但只有罕见的雌激素和孕激素受体表达(3)。转移是腮腺癌演变的共同特征。然而,胃肠道转移,尤其是阑尾转移,是非常罕见的。阑尾恶性转移的固有性质导致阑尾炎的晚期表现,穿孔发生率高,与死亡率和发病率增加有关(1)。我们描述了一个病例,患者因腮腺涎管癌转移累及蚓状阑尾穿孔而表现为急性腹部。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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