[Pulmonary fibrosis].

Abstract

Bleomycin rodent models for basic research and pharmacological efficacy studies. Investigation of in-vivo efficacy of therapeutic candidates for preventive or therapeutic IPF treatment. Invasive but repetitive lung function measurements for monitoring of bleomycin-induced lung injury and fibrosis without destruction of the organism. Integration of histological examination as a qualitative method to assess IPF. PULMONARY FIBROSIS: IN-VIVO BLEOMYCIN MODELS FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE ITEM