Analysis of Medical Slide Images Processing using Depth Learning in Histopathological Studies of Cerebellar Cortex Tissue

Abstract

—Today, with the advancement of science and technology, artificial intelligence evolves and grows along with human beings. Clinical specialists rely only on their knowledge and experience, as well as the results of complex and time-consuming clinical trials, despite the inevitable human errors of diagnosis work. Performing malignant and dangerous diseases, the use of machine learning makes it clear that the ability and capacity of these techniques are beneficial to help correctly diagnose diseases, reduce human error, improve diagnosis, and start treatment as soon as possible. In diseases, image processing and artificial intelligence is widely used in medicine and applied in stereological, histopathology. One of the essential activities for diagnosing the disease using artificial intelligence and machine learning is the fragmentation of images and classification of medical images, which is used to diagnose the disease with the help of images of the patient obtained from medical devices. In this article, we have worked on classifying medical histopathological images of brain tissue. The images are not of good quality due to sampling with standard equipment, and an attempt is made to improve the quality of the images by operating. Also, all images are segmented using the U-NET algorithm. In order to improve performance in classification, segmented images are used to classify images into two classes, normal and abnormal, instead of the images themselves. The images in the data set used in this study have a small number of images. Due to the use of a convolutional neural network algorithm to extract the feature and classify the images, more images are needed. Therefore, the data amplification technique to overcome this problem is used. Finally, the convolutional neural network has been used to extract features from images and classify fragmented images. Experimental results shown that the proposed method presented better performance compared to other existing methods.