[Inflammation and Neurodegeneration in Patients with Early-Stageand Chronic Bipolar Disorder].

S. Karabulut, I. Tasdemir, U. Akcan, C. Küçükali, E. Tüzün, S. Çakır
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引用次数: 15

Abstract

OBJECTIVE The increase in the circulatory cytokine levels observed in patients with bipolar disorder (BD) may imply involvement of inflammation in the pathogenesis of mood disorders. However, the association between the inflammatory process and the stage and severity of illness is not well understood. In this study, our aim was to investigate the association between neuroinflammation and disease progression in the clinical course of BD. METHOD IL-6, TNF-α, IL-1 receptor antagonist (IL-1RA), neuronspecific enolase (NSE) and S100B were measured by ELISA in plasma samples of patients at early-stage BD (n=30), chronic BD (n=77) and healthy controls (n=30). RESULTS Chronic BD patients showed significantly increased levels of all measured inflammatory markers as compared to early-stage BD patients and the healthy controls. IL-6 and IL-1RA levels correlated with NSE and/or S100B levels and TNF-α levels correlated with Montgomery- Asberg Depression Rating Scale scores and Clinical Global Impression Scale scores. CONCLUSION Our results indicate that inflammation appears to be particularly associated with IL-1RA and IL-6 activity, progressing at later stages of BD and possibly associated with gliosis and neuronal loss.
[早期和慢性双相情感障碍患者的炎症和神经变性]。
目的:双相情感障碍(BD)患者循环细胞因子水平升高可能暗示炎症参与情绪障碍的发病机制。然而,炎症过程与疾病的分期和严重程度之间的关系尚不清楚。在本研究中,我们的目的是探讨BD临床过程中神经炎症与疾病进展之间的关系。方法采用ELISA法检测早期BD患者(n=30)、慢性BD患者(n=77)和健康对照组(n=30)血浆样本中的il -6、TNF-α、IL-1受体拮抗剂(IL-1RA)、神经元特异性烯醇化酶(NSE)和S100B。结果与早期BD患者和健康对照组相比,慢性BD患者各项炎症指标均显著升高。IL-6和IL-1RA水平与NSE和/或S100B水平相关,TNF-α水平与Montgomery- Asberg抑郁评定量表评分和临床总体印象量表评分相关。我们的研究结果表明,炎症似乎与IL-1RA和IL-6活性特别相关,在BD的晚期进展,可能与胶质瘤和神经元丢失有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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