New Strategies of Antibiotic Development

J. Ahmad, S. Nagar
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Abstract

Since discovery of wonder drug penicillin by Sir Alexander Flaming, many antibiotics have already been discovered while many others are in process of development and clinical evaluation. However a newly discovered antibiotics has a short valuable life time since its long term clinical use results into development of resistance in target pathogens rendering the antibiotics ineffective against its target(s)). Therefore for antibiotics to remain in demand for clinical use. So efforts are needed towards search for antibiotics with unique scaffolds and/or novel mechanism of action besides useful shelf and clinical life time. Some of  the promising strategies to accomplish this goal are: (a) Finding new antibiotics from old microbial sources, (b) Finding new microbial sources of antibiotics, (c) Accessing greater bacterial diversity thus exploiting known/unknown microbial sources in large numbers, (d) Adapting novel culture techniques. The paper draws focus on some valuable clues in finding new antibiotics
抗生素开发的新策略
自从亚历山大·弗莱明爵士发现神奇药物青霉素以来,许多抗生素已经被发现,而许多其他抗生素正在开发和临床评估过程中。然而,一种新发现的抗生素的宝贵生命周期很短,因为长期临床使用会导致目标病原体产生耐药性,使抗生素对其目标无效。因此,对抗生素的临床应用仍有需求。因此,除了有效的货架期和临床寿命外,还需要努力寻找具有独特支架和/或新的作用机制的抗生素。实现这一目标的一些有希望的战略是:(a)从旧的微生物来源中寻找新的抗生素,(b)寻找新的抗生素微生物来源,(c)获得更大的细菌多样性,从而大量利用已知/未知的微生物来源,(d)采用新的培养技术。本文将重点放在寻找新抗生素的一些有价值的线索上
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