INSTRUMENTAL AND LABORATORY STUDY OF JAW MINERALIZATION LEVEL IN FEMALE PATIENTS WITH ESTROGEN IMBALANCE

Abstract

Introduction: Prevention of dental caries and non-carious lesions associated withdemineralizing effect of estrogen imbalance in perimenopause women isrelevant problem in modern dentistry.The aim: To improve the effectiveness of prevention of caries and non-cariouslesions in female patients with estrogen imbalance.Materials and methods: 3 groups of patients were selected for the study (20women in each): the patients of the control group receiving no additionaltreatment, the patients of experimental group 1 receiving general therapy withcomplex calcium supplements, the patients of experimental group 2 receivinggeneral therapy of complex calcium medicines combined withaminobisphosphonates.To quantify bone density of the jaws by computed tomography method, X-rayattenuation scale, called the Hounsfield scale was used. Bone tissues of the jawswere studied using 3D cone beam computed tomography scanner PlanmecaProMax. Planmeca Romexis® software was used for data processing andinterpretation. Estrogen level was estimated in all patients to confirm itsimbalance. The level of serum acid phosphatase was determined for indirectstudy of osteoporosis degree.Results: At the beginning of the research, significant bone demineralization andincreased level of acidic phosphatase were observed in all groups of women. In6 months of treatment the Hounsfield index and the level of acidic phosphatasein the control group were almost unchanged; in experimental group 1 – 1571±44 HU and 4.93 ± 0.26 IU/l; in experimental group 2 – 1701±48 HU and 2.43± 0.18 IU/l.Conclusions: Combination therapy consisting of calcium phosphate withvitamin D3 and aminobisphosphonates used for 6 months increased bonemineralization by 13.05% and reduced the activity of acid phosphatase by64.2%. This therapeutic complex results in decreased destruction of bone tissueand enhances remineralization of bone tissue and dental hard tissues.Key words: teeth mineralization, osteoporosis, estrogen dysfunction, Hounsfieldindex.