DEVELOPMENT OF TECHNOLOGIES FOR OBTAINING ACTIVE PHARMACEUTICAL INGREDIENTS, MEDICINAL AND DIAGNOSTIC PREPARATIONS BASED ON LIPIDS IN UKRAINE

Abstract

In Ukraine, for 45 years (1975-2020), biotechnological and bionanotechnological studies were conducted to obtain lipid active phar­maceutical ingredients and create diagnostic and medicinal products. Phospholipids and glycolipids are important participants in biological reactions. Methods for obtaining highly purified phospholipid and ganglioside ingredients are proposed using technologi­cal methods of lipid chemistry and biotechnology. The authors have studied physicochemical and biological properties of phospholi­pids and gangliosides. The structure of the isolated lipid substances was confirmed. The studies of biological activity of the ganglio­sides with a number of models have confirmed their high biological activity: antiviral, reparative, immunostimulating. The studies allowed for creation a number of diagnostic lipid antigens and drugs, that were implemented in production in Ukraine and other countries. For the first time in CIS in Ukraine, liposomal forms of preparations having antitumor, antioxidant, anti-inflammatory and membrane-protective pharmacological properties have been developed. The scope of biotechnology application in this field is con­stantly expanding and is of interest to practical medicine and business now. And while the issues in this area are still far from over, it is already obvious that this line of research will allow for raising to a new level the development of methods of diagnosis and treat­ment of human diseases in the future. It should be noted that biotechnological studies lipids and liposomal forms are the basis of this line of research. Nanoforms of pharmaceuticals, in particular liposomes, can solve the problem of giving new unique properties to known active pharmaceutical ingredients and consequently increase therapeutic efficacy. Research on obtaining liposomal drugs based on hydrophobic antioxidants is carried out at the Department of Biotechnology, Biophysics and Analytical Chemistry, NTU "KhPI".