Targeting Ion Channel TRPM4.

IF 2.8 2区社会学 Q1 Social Sciences

Annals of the American Academy of Political and Social Science Pub Date : 2022-12-21 DOI:10.2533/chimia.2022.1039

Barbara Preti, Jean-Sébastien Rougier, Irida Papapostolou, Florian Bochen, Christian E Gerber, Hugues Abriel, Martin Lochner, Christine Peinelt

引用次数: 1

Abstract

The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecules that block TRPM4 in the low µM range. Furthermore, we investigated the pathophysiology of TRPM4 in cardiac conditions, immune diseases and cancer using these novel inhibitors, molecular biology techniques and functional assays.

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靶向离子通道 TRPM4。

瞬时受体电位美拉抑素4 (TRPM4)离子通道普遍表达。TRPM4的失调和/或功能突变可导致多种疾病。在我们的研究中，我们筛选了TRPM4抑制剂，并确定了在低µM范围内阻断TRPM4的小分子。此外，我们利用这些新型抑制剂、分子生物学技术和功能分析研究了TRPM4在心脏病、免疫疾病和癌症中的病理生理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of the American Academy of Political and Social Science Multiple-

CiteScore

5.20

自引率

0.00%

发文量

期刊介绍： The AAPSS seeks to promote the progress of the social sciences and the use of social science knowledge in the enrichment of public understanding and in the development of public policy. It does so by fostering multidisciplinary understanding of important questions among those who create, disseminate, and apply the social sciences, and by encouraging and celebrating talented people who produce and use research to enhance public understanding of important social problems.