Development of computational pipeline for antibody identification against specific conformations of PD-1.

Abstract

in literature. Finally, the modified antibody does not recognize the original antigen, since while the original antibody had its correct pose readily identified, by docking, the mutated antibody not even generated the crystallographic pose. Conclusion: Here we described and applied a new protocol for computationally design new antibodies taking advantage of the structural variability of CDRs loops at low computational cost.