Spotlight on the Protein Corona of Liposomes

N. Onishchenko, D. Tretiakova, E. Vodovozova
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引用次数: 29

Abstract

Although an established drug delivery platform, liposomes have not fulfilled their true potential. In the body, interactions of liposomes are mediated by the layer of plasma proteins adsorbed on the surface, the protein corona. The review aims to collect the data of the last decade on liposome protein corona, tracing the path from interactions of individual proteins to the effects mediated by the protein corona in vivo. It offers a classification of the approaches to exploitation of the protein corona-rather than elimination thereof-based on the bilayer composition-corona composition-molecular interactions-biological performance framework. The multitude of factors that affect each level of this relationship urge to the widest implementation of bioinformatics tools to predict the most effective liposome compositions relying on the data on protein corona. Supplementing the picture with new pieces of accurately reported experimental data will contribute to the accuracy and efficiency of the predictions.
脂质体蛋白冠的研究进展
虽然脂质体是一个成熟的药物传递平台,但它并没有发挥其真正的潜力。在体内,脂质体的相互作用是由吸附在表面的血浆蛋白层介导的,即蛋白冠层。本综述旨在收集近十年来脂质体蛋白冠的数据,追踪从单个蛋白的相互作用到体内蛋白冠介导的效应的路径。它提供了一种基于双层组成-电晕组成-分子相互作用-生物性能框架的蛋白质冠状蛋白开发方法的分类,而不是消除它们。影响这种关系的各个层面的众多因素促使生物信息学工具的最广泛实施,以预测最有效的脂质体组成依赖于蛋白质冠的数据。用新的准确报告的实验数据来补充这一图景,将有助于预测的准确性和效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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