Applications of microdialysis methodology in nonhuman primates: practice and rationale.

Abstract

This review provides a comprehensive summary of the use of microdialysis procedures in nonhuman primates. Using these methods in primates is feasible, including both the anesthetized and awake preparations. The latter permit neurochemical sampling during complex information processing and behavioral performance. The close homology in structure and function between human and nonhuman primate brain makes using nonhuman primates particularly appealing, and the literature suggests that their use has provided instances of unique insight into brain structure and function. The continued use of these methods in areas such as the neurobiology of addiction, affective disorders, and psychosis will help in our ever-increasing understanding of the complex pathophysiologies of these disorders.