Effects of casein on iodine metabolism in body and thyroid of mice under excessive iodine

Q3 Medicine

中华地方病学杂志 Pub Date : 2011-11-20 DOI:10.3760/CMA.J.ISSN.1000-4955.2011.06.008

Ying Li, Y. Jun, Zhi-yi Zhang, Shu-Bin Zhang, Shou-Jun Liu, Xiao-hui Sux, Yong-xiang Ye, S. Ming, Xin Zhao, Yan Liu

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Abstract

Objective To observe the effects of casein on iodine metabolism in blood,urine and thyroid of mice under excessive iodine.Methods A 2 by 3 factorial design was used in the experiment.The levels of iodine and casein were 50 and 600 μg/L in drinking water and 0( Ⅰ ),10％( Ⅱ ),20％( m ) in food,respectively.After six and twelve months,iodine content in serum,thyroid gland and urine was determined by arsenic-cerium catalyzed spectrophotometry.Results In six months,the levels of serum iodine in 50 Ⅰ,50 Ⅱ,50Ⅲ,600 Ⅰ,600 Ⅱ,and 600Ⅲ groups were (85.59 ± 8.78),(64.59 ± 9.06),(72.53 ± 11.69),(110.04 ± 9.37),(81.06 ± 9.94),(86.63 ± 19.59)μg/L,respectively; the levels of iodine content in thyroid gland were (0.21 ± 0.09),(0.29 ±0.08),(0.24 ± 0.05),(0.50 ± 0.10),(0.37 ± 0.13),(0.42 ± 0.12)g/kg,respectively; the levels of urinary iodine median were 87.5,68.1,105.5,746.5,828.3,1014.2 μg/L,respectively.The variance analysis results of factorial design showed iodine and casein significantly influenced the serum iodine level(F =27.95,18.52,all P ＜0.05),however,there was no interaction between the two(F =0.81,P ＞ 0.05); iodine significantly influenced the iodine content in thyroid gland(F =31.35,P ＜ 0.05),the presence of iodine interacted with casein(F =3.34,P ＜0.05).In twelve months,the levels of serum iodine were (88.54 ± 12.33),(72.45 ± 7.73),(72.93 ± 13.61),( 106.26 ± 12.00),(90.03 ± 7.90),( 104.88 ± 11.67)μg/L,respectively; the levels of iodine content in thyroid gland were (0.58 ± 0.12),(0.40 ± 0.14),(0.69 ± 0.16),(0.84 ± 0.13),(0.89 ± 0.13),(1.02 ± 0.11 )g/kg,respectively;the levels of urinary iodine median were 104.8,121.5,102.7,829.1,1080.8,895.2 μg/L,respectively.The variance analysis results of factorial design showed iodine and casein significantly influenced the iodine content in serum and thyroid gland (F =42.78,7.42 and 66.62,7.90,all P ＜ 0.05),however,there was no interaction between the two(F =1.93,2.31,all P ＞ 0.05).Conclusions Long-term intake of iodine can significantly increase the iodine content in serum,thyroid gland and urine,but casein may accelerate iodine excretion and partly reduce the effect. Key words: Iodine; Caseins; Thyroid

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酪蛋白对碘过量小鼠体内及甲状腺碘代谢的影响

目的观察酪蛋白对高碘小鼠血、尿及甲状腺碘代谢的影响。方法采用2 × 3因子设计。饮用水中碘和酪蛋白含量分别为50和600 μg/L，食品中碘和酪蛋白含量分别为0(Ⅰ)、10%(Ⅱ)和20%(m)。6个月和12个月后用砷铈催化分光光度法测定血清、甲状腺和尿液中的碘含量。结果6个月内，50Ⅰ、50Ⅱ、50Ⅲ、600Ⅰ、600Ⅱ、600Ⅲ组血清碘水平分别为(85.59±8.78)、(64.59±9.06)、(72.53±11.69)、(110.04±9.37)、(81.06±9.94)、(86.63±19.59)μg/L;甲状腺碘含量分别为(0.21±0.09)、(0.29±0.08)、(0.24±0.05)、(0.50±0.10)、(0.37±0.13)、(0.42±0.12)g/kg;尿碘中位数分别为87.5、68.11、105.5、746.5、828.3、1014.2 μg/L。因子设计方差分析结果显示，碘和酪蛋白显著影响血清碘水平(F =27.95,18.52，均P <0.05)，但两者之间无交互作用(F =0.81,P <0.05);碘显著影响甲状腺碘含量(F =31.35,P <0.05)，碘的存在与酪蛋白相互作用(F =3.34,P <0.05)。12个月血清碘水平分别为(88.54±12.33)、(72.45±7.73)、(72.93±13.61)、(106.26±12.00)、(90.03±7.90)、(104.88±11.67)μg/L;甲状腺碘含量分别为(0.58±0.12)、(0.40±0.14)、(0.69±0.16)、(0.84±0.13)、(0.89±0.13)、(1.02±0.11)g/kg，尿碘中位数分别为104.8、121.5、102.7、829.1、1080.8 895.2 μg/L。因子设计方差分析结果显示，碘和酪蛋白显著影响血清和甲状腺碘含量(F =42.78、7.42和66.62、7.90，均P < 0.05)，但两者之间无交互作用(F =1.93、2.31，均P < 0.05)。结论长期摄入碘可显著提高血清、甲状腺和尿液中碘的含量，但酪蛋白可加速碘的排泄，部分降低其作用。关键词:碘;——酪蛋白;甲状腺

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来源期刊

中华地方病学杂志我国对人类健康危害特别严重的地方性疾病：克山病、大骨节病、碘缺乏病、地方性氟中毒、地方性砷中毒、鼠疫、布鲁氏菌病、寄生虫、新冠肺炎等疾病，同时还报道多发性自然疫源性疾病。

CiteScore

1.60

自引率

0.00%

发文量

8714

期刊介绍： The Chinese Journal of Endemiology covers predominantly endemic diseases threatening health of the people in the areas affected by the diseases including Keshan disease, Kaschin-Beck Disease, iodine deficiency disorders, endemic fluorosis, endemic arsenism, plague, epidemic hemorrhagic fever, brucellosis, parasite diseases and the diseases related to local natural and socioeconomic conditions; and reports researches in the basic science, etiology, epidemiology, clinical practice, control as well as multidisciplinary studies on the diseases.