Renin inactivation in vitro in pregnant and post partum rabbit uterine and kidney tissue.

Abstract

In slices of pregnant and post partum rabbit uterus 80 per cent of the endogenous renin was gradually inactivated during incubation in vitro at 37°C for 44 hours. In slices of rabbit kidney only 30 per cent was inactivated. Contrary to this there was only a slight, inconsistent, decrease in renin content in similarly incubated homogenates and extracts of uterine and renal tissue. The results show that intact tissue from both the kidney and especially the uterus have a capacity for inactivation of renin.