Assessment of Biochemical Changes Among Covid-19 Cases in a Tertiary Hospital of Bangladesh During Early Pandemic

Indian journal of preventive and social medicine Pub Date : 2022-01-09 DOI:10.3329/jopsom.v40i1.56689

S. Mithun, S. M. Md Abdullah, Sm Nurul Irfan

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Abstract

Background: Corona virus disease 2019 (COVID-19) involves various organs of the body causing several biochemical changes which plays an essential role in estimating the patients’ condition and prognosis, directing treatment, and even evaluating the curative effects. The present study aimed to assess the biochemical changes among the COVID-19 patients during early pandemic. Methods: This cross sectional study was conducted at Combined Military Hospital (CMH) Dhaka among purposively selected 237 confirm COVID-19 cases. Data were collected through face to face interview and review of medical records using a pre-tested semi-structured questionnaire. The study was conducted in the Combined Military Hospital Dhaka from 15 April 2020 to 31 May 2020 Results: Highest number of the respondents were in the age group of 31-40 years (37.1%) with male predominance (83.1%). About 95.6% were Muslim and 58.6% were educated up to secondary level. About 87.8% had contact with a confirmed case and having 47.7%, 37.2%, 15.1% cardiovascular, endocrine and respiratory comorbidities respectively. Fever (34.6%) was the most common presenting symptoms followed by cough (22.9%), sore throat (10.6%). Neutrophilia observed in 26.16%, lymphopenia in 20.7%, thrombocytopenia in 14.3% cases, 30.0% with positive D-dimer test, 22.4% either sepsis or systemic infection in procalcitonin estimation, 28.3% with increased ferritin, 28.7% with positive C reactive protein, 21.1% with increased LDH. Chi-square analysis revealed a statistically significant association between cardiovascular and endocrine diseases with several biochemical changes (p<0.05). Conclusion: Early identification of various biochemical changes would help the physician for appropriate assessment and management. JOPSOM 2021; 40(1): 34-42

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大流行早期孟加拉国某三级医院新冠肺炎病例生化变化评估

背景:2019冠状病毒病(COVID-19)涉及人体多个器官，引起多种生化变化，在判断患者病情和预后、指导治疗甚至评估疗效方面发挥重要作用。本研究旨在评估COVID-19患者在大流行早期的生化变化。方法:在达卡联合军队医院(CMH)进行横断面研究，有目的地选择237例新冠肺炎确诊病例。通过面对面访谈和使用预测试的半结构化问卷审查医疗记录来收集数据。该研究于2020年4月15日至2020年5月31日在达卡联合军事医院进行。结果:受访者最多的是31-40岁年龄组(37.1%)，男性占多数(83.1%)。95.6%的人是穆斯林，58.6%的人受过中等以上教育。与确诊病例有过接触的占87.8%，心血管、内分泌、呼吸合并症分别占47.7%、37.2%、15.1%。发烧(34.6%)是最常见的症状，其次是咳嗽(22.9%)、喉咙痛(10.6%)。中性粒细胞增多26.16%，淋巴细胞减少20.7%，血小板减少14.3%，d -二聚体试验阳性30.0%，降钙素原估计败血症或全系统感染22.4%，铁蛋白升高28.3%，C反应蛋白阳性28.7%，LDH升高21.1%。卡方分析显示，心血管和内分泌疾病与多项生化变化有统计学意义(p<0.05)。结论:早期发现各种生化变化有助于医师进行适当的评估和处理。JOPSOM 2021;(1): 40 34-42

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Indian journal of preventive and social medicine

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