The Noninvasive Evaluation for Minimally Invasive Pediatric Epilepsy Surgery (MIPES): A Multimodal Exploration of the Localization-Based Hypothesis

IF 0.2 Q4 PEDIATRICS
Deepankar Mohanty, Michael M. C. Quach
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引用次数: 0

Abstract

Abstract Minimally invasive pediatric epilepsy surgery (MIPES) is a rising technique in the management of focal-onset drug-refractory epilepsy. Minimally invasive surgical techniques are based on small, focal interventions (such as parenchymal ablation or localized neuromodulation) leading to elimination of the seizure onset zone or interruption of the larger epileptic network. Precise localization of the seizure onset zone, demarcation of eloquent cortex, and mapping of the network leading to seizure propagation are required to achieve optimal outcomes. The toolbox for presurgical, noninvasive evaluation of focal epilepsy continues to expand rapidly, with a variety of options based on advanced imaging and electrophysiology. In this article, we will examine several of these diagnostic modalities from the standpoint of MIPES and discuss how each can contribute to the development of a localization-based hypothesis for potential surgical targets.
微创小儿癫痫手术(MIPES)的无创评估:基于定位假设的多模式探索
微创小儿癫痫手术(MIPES)是一项新兴的治疗局灶性药物难治性癫痫的技术。微创手术技术是基于小范围的局部干预(如实质消融或局部神经调节),从而消除癫痫发作区或中断更大的癫痫网络。精确定位癫痫发作区,划定雄辩皮层,以及绘制导致癫痫发作传播的网络是实现最佳结果所必需的。局灶性癫痫的术前、无创评估工具箱继续迅速扩大,有多种基于先进成像和电生理学的选择。在本文中,我们将从MIPES的角度研究这些诊断模式中的几种,并讨论每种模式如何有助于为潜在手术目标建立基于定位的假设。
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来源期刊
自引率
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发文量
21
期刊介绍: The Journal of Pediatric Epilepsy is an English multidisciplinary peer-reviewed international journal publishing articles on all topics related to epilepsy and seizure disorders, epilepsy surgery, neurology, neurosurgery, and neuropsychology in childhood. These topics include the basic sciences related to the condition itself, the differential diagnosis, natural history, and epidemiology of seizures, and the investigation and practical management of epilepsy (including drug treatment, neurosurgery and non-medical and behavioral treatments). Use of model organisms and in vitro techniques relevant to epilepsy are also acceptable. Journal of Pediatric Epilepsy provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis and treatment of childhood epilepsy.
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