Photosensitizer accumulation in the bladder mucosa in chronic cystitis

中国激光医学杂志 Pub Date : 2021-01-29 DOI:10.37895/2071-8004-2020-24-2-3-9-14

A. Baranov, A. Kornev, A. A. Boriskin, R. D. Mustafayev, V. Derbenev, D. Gorin, K. T. Efendiyev

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Abstract

Purpose . To study the accumulation of photosensitizer Photoditazine in the bladder mucous in chronic cystitis. Material and methods . 22 patients with chronic cystitis were taken into the study. The time of Photoditazine accumulation in the bladder mucous was determined with a multi-channel optical fiber spectroanalyzer («LESA-01-BIOSPEC»). Photodynamic therapy (PDT) was done with laser «ATKUS-2» having adjustable output power up to 2 W and wavelength 661 ± 0.03 nm. Results . The performed fluorescence spectroscopy has revealed that the maximal accumulation time of Photoditazine in the bladder mucous in chronic cystitis is 120–150 minutes. After laser exposure, by spectroscopy finings, fluorescence intensity decreases by 72.3% which indicates a pronounced photosensitizer excitation and an active photodynamic reaction. Conclusion . The optimal time for laser photodynamic therapy in chronic cystitis is 2–2.5 hours after photosensitizer injection. Spectroscopy findings after laser exposure demonstrate the effectiveness of photodynamic therapy in chronic cystitis.

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来源期刊

中国激光医学杂志

自引率

0.00%

发文量

5650

期刊介绍： The main columns of "Chinese Journal of Laser Medicine & Surgery" include treatises, which report the latest research results in basic research and clinical trials in the field of laser medicine; comprehensive reviews of the latest research progress in laser medicine at home and abroad. In addition, there are short reports and excerpts from foreign journals, conference news and other columns. The journal has published a large number of papers on basic research on laser medicine and applied research in various clinical subjects, aiming to play a positive role in promoting the application of laser in medicine and improving the level of laser medicine research.