The impact of white blood cell count and hemoglobin level on the response to radiotherapy in patients with colorectal cancer

Biomarkers and Genomic Medicine Pub Date : 2014-12-01 DOI:10.1016/j.bgm.2014.08.004

Hsueh-Chiao Liu , Ming-Yii Huang , Jaw-Yuan Wang , Long-Sen Chang , Shiu-Ru Lin

{"title":"The impact of white blood cell count and hemoglobin level on the response to radiotherapy in patients with colorectal cancer","authors":"Hsueh-Chiao Liu , Ming-Yii Huang , Jaw-Yuan Wang , Long-Sen Chang , Shiu-Ru Lin","doi":"10.1016/j.bgm.2014.08.004","DOIUrl":null,"url":null,"abstract":"<div><p>Radiotherapy (RT) plays a much more important role in the treatment of colorectal cancer when it can be used to reduce the size of a tumor prior to the local excision of the cancer. In order to find other factors possibly related to radiosensitivity, we evaluated the relationships between circulating blood cell counts and RT effects. In 81 cases of rectal cancer, we examined white blood cell and platelet counts, as well as hemoglobin (Hb) levels, prior to RT, and also investigated their associations with the treatment response rate and with other clinicopathological factors. The patients with anemia had significantly worse RT responses, whereas patients with high white blood cell counts (≥7400/μL) showed better responses (<em>p</em> < 0.001). Cancer patients with low Hb levels do not respond as well to RT as nonanemic patients (<em>p</em> = 0.018). In colorectal cancer patients, white blood cell counts and Hb levels have a significant impact on the responsiveness to RT.</p></div>","PeriodicalId":100178,"journal":{"name":"Biomarkers and Genomic Medicine","volume":"6 4","pages":"Pages 171-174"},"PeriodicalIF":0.0000,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bgm.2014.08.004","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomarkers and Genomic Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214024714000677","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 3

Abstract

Radiotherapy (RT) plays a much more important role in the treatment of colorectal cancer when it can be used to reduce the size of a tumor prior to the local excision of the cancer. In order to find other factors possibly related to radiosensitivity, we evaluated the relationships between circulating blood cell counts and RT effects. In 81 cases of rectal cancer, we examined white blood cell and platelet counts, as well as hemoglobin (Hb) levels, prior to RT, and also investigated their associations with the treatment response rate and with other clinicopathological factors. The patients with anemia had significantly worse RT responses, whereas patients with high white blood cell counts (≥7400/μL) showed better responses (p < 0.001). Cancer patients with low Hb levels do not respond as well to RT as nonanemic patients (p = 0.018). In colorectal cancer patients, white blood cell counts and Hb levels have a significant impact on the responsiveness to RT.

查看原文本刊更多论文

白细胞计数和血红蛋白水平对结直肠癌患者放疗反应的影响

放疗(RT)在结直肠癌的治疗中发挥着更重要的作用，因为它可以在局部切除肿瘤之前缩小肿瘤的大小。为了找到可能与放射敏感性相关的其他因素，我们评估了循环血细胞计数与放疗效果之间的关系。在81例直肠癌患者中，我们检查了放疗前的白细胞和血小板计数以及血红蛋白(Hb)水平，并调查了它们与治疗反应率和其他临床病理因素的关系。贫血患者的RT反应明显较差，而白细胞计数高(≥7400/μL)患者的RT反应较好(p <0.001)。低Hb水平的癌症患者对放疗的反应不如非贫血患者(p = 0.018)。在结直肠癌患者中，白细胞计数和Hb水平对RT的反应性有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomarkers and Genomic Medicine

自引率

0.00%

发文量