High Glucose Enhances Skin Sensitizer-induced NRF2 Activation In Vitro

Abstract

Hyperglycemia, blood glucose levels above 2.0 g/L, is one of the major pathophysiological factors causing late complications in diabetes [1, 2]. Reactive Oxygen Species (ROS) are increased by hyperglycemia [3]. Oxidative damage in individual cells may reach a sufficient threshold to cause DNA strand breaks and induce cell death [4]. Therefore, hyperglycemia-induced oxidative stress is one of the responsible factors for the pathology of diabetic complications.