Phytochemical Profile and Biological Activities of Ethylacetate Extract of Peanut (Arachis hypogaea L.) Stems: In-Vitro and In-Silico Studies with Bibliometric Analysis

Q1 Earth and Planetary Sciences

Indonesian Journal of Science and Technology Pub Date : 2022-12-28 DOI:10.17509/ijost.v8i2.54822

I. Sahidin, N. Nohong, M. Manggau, A. Arfan, W. Wahyuni, Iren Meylani, M. Malaka, Nurisma Rahmatika, A. W. Yodha, N. U. E. Masrika, A. Kamaluddin, A. Sundowo, S. Fajriah, Rathapon Asasutjarit, A. Fristiohady, Rina Maryanti, Nur Indri Rahayu, M. Muktiarni

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引用次数: 2

Abstract

The utilization of the stems, leaves, and hulls of peanuts (Arachis hypogea) is not as popular as the seeds. This study aimed to investigate the chemical contents and pharmacological activities of A. hypogaea stems in-vitro and in-silico. This study was also completed with bibliometric analysis. The methanol extract (ME) was reextracted by ethylacetate to get ethyl acetate extract (EAE). The chemical contents of EAE were analyzed by phytochemical screening, Liquid Chromatography-Mass Spectroscopy (LC-MS/MS), TPC (Total Phenolic Content), and TFC (Total Flavonoid Content). In-vitro and in-silico studies evaluated antioxidant potency, toxicity, and cytotoxicity toward MCF-7 cell lines. The results showed that EAE contained terpenoids, flavonoids, alkaloids, and phenolics which were supported by LC-MS/MS data. The EAE was categorized as a very strong antioxidant and moderately active in both cytotoxicity and toxicity.

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花生乙酸乙酯提取物的植物化学特征及生物活性研究茎:体外和计算机研究与文献计量分析

花生(arachhis hypogea)的茎、叶和壳的利用不如种子受欢迎。本研究旨在研究金合欢茎的化学成分及体外和体外的药理活性。本研究亦以文献计量学分析完成。甲醇提取物(ME)经乙酸乙酯再萃取得到乙酸乙酯提取物(EAE)。采用植物化学筛选、液相色谱-质谱联用(LC-MS/MS)、总酚含量(TPC)、总黄酮含量(TFC)等方法对EAE的化学成分进行分析。体外和计算机研究评估了MCF-7细胞系的抗氧化能力、毒性和细胞毒性。结果表明，EAE中含有萜类、黄酮类、生物碱和酚类物质，与LC-MS/MS数据一致。EAE被归类为很强的抗氧化剂，在细胞毒性和毒性方面都具有中等活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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