Association of Hp 1-1 with liver disorders among Sudanese patients

Abstract

An assessment study was conducted to investigate the role of serum Haptoglobin (Hp) phenotypes in Sudanese patients with liver diseases on susceptibility to attain these diseases. Hp phenotypes were determined by separating sera supplemented with haemolysate on 4.7% polyacrylamide gel electrophoresis followed by Benzidine staining. The number of individuals with Hp1-1 was found significantly higher among patients with hepatitis B virus infection (HBV) (P<0.0005), patients with liver cirrhosis (P<0.0005) and patients with liver cancer (P<0.002) when compared to healthy control group. We suggest an association between Hp1-1 and susceptibility to HBV, liver cirrhosis and liver cancer that might be further associated with the development of different pathological complications.