Chanwuyi Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism

IF 1.6 Q3 CLINICAL NEUROLOGY

NeuroSci Pub Date : 2021-06-07 DOI:10.3390/NEUROSCI2020015

A. Chan, Yvonne M. Y. Han, S. L. Sze, C. Wong, I. Chu, M. Cheung

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Abstract

Given the association between deviated inflammatory chemokines, the pathogenesis of autism spectrum disorders (ASD), and our previous findings of the Chanwuyi Lifestyle Medicine Program regarding improved cognitive and behavioral problems in ASD, the present study aims to explore if this intervention can alter pro-inflammatory chemokines concentration. Thirty-two boys with ASD were assigned to the experimental group receiving the Chanwuyi Lifestyle Medicine Program for 7 months or the control group without a change in their lifestyle. The experimental group, but not the control group, demonstrated significantly reduced CCL2 and CXCL8, a trend of reduction in CCL5, and elevation of CXCL9. The experimental group also demonstrated significantly reduced social communication problems, repetitive/stereotypic behaviors, and hyperactive behaviors. The present findings support the potential efficacy and applicability of the Chanwuyi Lifestyle Medicine Program for reducing both behavioral problems and immunological dysfunction in ASD. Further studies are warranted to verify its treatment effect and its association with brain functions.

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“禅五一”生活方式药物计划减轻自闭症患者的免疫偏差，改善其行为

鉴于炎性趋化因子偏离与自闭症谱系障碍(ASD)发病机制之间的关联，以及我们之前在Chanwuyi生活方式医学项目中发现的改善ASD认知和行为问题的结果，本研究旨在探讨这种干预是否可以改变促炎性趋化因子的浓度。将32名ASD男孩分为实验组和对照组，实验组接受“Chanwuyi Lifestyle Medicine Program”治疗7个月，对照组不改变生活方式。实验组CCL2和CXCL8明显降低，CCL5有降低的趋势，CXCL9有升高的趋势，而对照组没有。实验组的社会沟通问题、重复/刻板行为和过度活跃行为也显著减少。本研究结果支持Chanwuyi Lifestyle Medicine Program在减少ASD的行为问题和免疫功能障碍方面的潜在功效和适用性。需要进一步的研究来验证其治疗效果及其与脑功能的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroSci

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0.00%

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审稿时长

11 weeks