Moisturizing Lotion Formulation on Tropical Skin based on Cananga Oil (Cananga odorata), Kaffir Lime Oil (Citrus hystrix DC) and Patchouli Oil (Pogostemon cablin) as a Bioactive

Vivi Nurhadianty, Indah Amalia Amri, S. Kanza, Luh Putu Maharani, C. Cahyani
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Abstract

: Indonesia is a tropical country with an average room temperature 37 o C and humidity in each region are varies. These conditions make the skin sweat so that the skin loses water. If it left unchecked, it can cause a variety of skin diseases. Proper moisturizer can reduce and prevent damage to the skin. Essential oils have specific bioactive contents such as an antioxidant, anti-inflammatory and antibacterial properties. Previous research has shown that Cananga oil has high anti-bacterial and antioxidant activity (close to 80% ascorbic acid). Citronellal compounds in kaffir lime oil can be used as an antimicrobial and anti-inflammatory. In addition to essential oils, sunflower seed oil is used as a carrier oil to prevent irritation due to high concentrations of essential oils. Sunflower Oil contains oleic and linoleic acids which can improve water absorption in the skin as well as antioxidants. Research on the process of extracting essential oils has been widely carried out, but the use of essential oils that have bioactive content has not been done much. Lotion is one of skin care that is commonly used on the skin. This research aims to get the best formulation in making cananga oil, kaffir lime oil, patchouli oil based lotion which have high antioxidant activity, high hydration effect and good consistency. Essential oils as active ingredients are added with various compositions then formulated and tested in vivo and in vitro. The urgency of this research is to get a lotion formulation from essential ingredients suitable for the skin of the tropics so that later it can be eliminated and support UB especially in welcoming PTNBH. The results showed that the lotion is stabled after stability testing for 7 cycles of cooling 4oC and heating 40 o C. The pH test results also indicate that the lotion has a pH between 7.05 - 7.95 which is in accordance with SNI standards. The lotion spread test shows that the greater the load given, the greater the spread diameter of the lotion. The best lotion dispersion is found in Formula V4, W2 with a bio active concentration: base lotion of 1:11,5. For the results of in vitro testing of mice, it was found that there is no lotion formula that causes allergies.
热带皮肤保湿乳液配方,以甘楠油(Cananga odorata)、卡菲莱姆油(Citrus hystrix DC)和广藿香油(Pogostemon cablin)为生物活性成分
印度尼西亚是一个热带国家,平均室温37℃,每个地区的湿度都不同。这些情况使皮肤出汗,使皮肤失去水分。如果不加以控制,它会引起各种皮肤疾病。适当的润肤霜可以减少和防止对皮肤的伤害。精油具有特定的生物活性成分,如抗氧化、抗炎和抗菌特性。先前的研究表明,加纳油具有很高的抗菌和抗氧化活性(接近80%的抗坏血酸)。柠檬油中的香茅醛化合物可作为抗菌和抗炎药。除了精油,葵花籽油被用作基础油,以防止刺激由于高浓度的精油。葵花籽油含有油酸和亚油酸,可以提高皮肤的吸水率和抗氧化剂。对提取精油的工艺进行了广泛的研究,但对具有生物活性成分的精油的利用却做得不多。乳液是一种常用的皮肤护理产品。本研究的目的是得到以甘楠油、卡菲尔酸橙油、广藿香油为基础的抗氧化活性高、水合效果好、稠度好的洗剂的最佳配方。作为活性成分的精油与各种组合物一起添加,然后在体内和体外配制和测试。这项研究的急迫性是得到一种适合热带皮肤的基本成分的洗液配方,以便以后可以消除它,并支持UB,特别是欢迎PTNBH。结果表明,经冷却4℃、加热40℃7次循环稳定性测试后,乳液稳定,pH值测试结果也表明,乳液的pH值在7.05 ~ 7.95之间,符合SNI标准。乳液的扩散试验表明,给定的载荷越大,乳液的扩散直径越大。配方V4, W2的生物活性浓度为1:11,5时,乳液分散效果最佳。对于小鼠体外试验的结果,发现没有引起过敏的洗剂配方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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