A macrophage at work

IF 0.3 4区医学 Q4 ONCOLOGY

Uhod-Uluslararasi Hematoloji-Onkoloji Dergisi Pub Date : 2017-01-01 DOI:10.4999/UHOD.171981

B. Kahwash, S. Kahwash, G. Tan

引用次数: 0

Abstract

In this image a macrophage in cerebrospinal fluid (CSF) is caught doing what it does best; cleansing the environment of objects that don’t belong. The patient, a 6-month-old girl, initially presented with choking and feeding difficulty. Brain MRI revealed a large tumour in the right posterior fossa, originating from the inferior aspect of the right cerebellar hemisphere. She underwent surgery to remove the tumour a few days before the CSF was sampled. Histologic examination confirmed the diagnosis of Atypical Teratoid Rhabdoid Tumor. The macrophage is seen stretching its pseudopods –like a well-trained athlete reaching out to make a catch– to grab a red blood cell (RBC) (short arrow). Particles of digested debris from other RBCs are noted within its cytoplasm (long arrow) – evidence that this phagocytic act had been performed several times before. Macrophages, via chemotaxis, play a significant role in cleansing surgical sites by removing debris and organisms.

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巨噬细胞在起作用

在这张图片中，脑脊液(CSF)中的巨噬细胞正在做它最擅长的事情;清除不属于该环境的对象。患者为一名6个月大的女婴，最初表现为窒息和进食困难。脑MRI显示右后颅窝有一个大肿瘤，起源于右脑半球的下侧面。在脑脊液取样前几天，她接受了切除肿瘤的手术。病理检查证实为不典型畸胎瘤样横纹肌样瘤。巨噬细胞伸展它的假足，就像一个训练有素的运动员伸出手去抓球一样——抓住红细胞(短箭头)。在其细胞质中可以看到来自其他红细胞的消化碎片颗粒(长箭头)，这表明这种吞噬行为之前已经进行了几次。巨噬细胞通过趋化作用，在清除手术部位的碎片和有机体中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Uhod-Uluslararasi Hematoloji-Onkoloji Dergisi ONCOLOGY-

CiteScore

1.60

自引率

16.70%

发文量

审稿时长

>12 weeks

期刊介绍： Target of Publication is the public representation of new scientific results of fundamental, problem-oriented, and search scientific investigations; analytical articles and reviews by actual scientific problems of coal mining industry, short reports in the field of coal mining industry, including the results of work of scientific meetings, conferences, summit’s and congresses in the field of mining. The basic purpose of the journal is the promotion of innovative activity in the coal mining industry by highlighting and discussing the results of basic and applied research, the experience in applying results of innovation for the development of the Russian coal mining. The most important tasks of the journal are: the generalization of scientific and practical achievements of specialists in the field of coal mining industry, specializing in the implementation of promising basic and applied research and development of priorities of high technologies; the scientific concept of the publication; the publication of the latest achievements in the field of innovation in coal mining industry. The journal lays special emphasis on methodical elaborations, analytical investigations in the sphere of coal mining. Targets of Journal are in publication of new results of scientific investigations performed by scientists, post-graduate students, and doctoral candidates performed by from higher schools, Russian Academy of Sciences, other scientific organizations of Russia, CIS countries, and foreign universities