The role of micronutrients in the response to ambient air pollutants: Potential mechanisms and suggestions for research design

IF 6.4 2区医学 Q1 ENVIRONMENTAL SCIENCES

Journal of Toxicology and Environmental Health-Part B-Critical Reviews Pub Date : 2017-01-02 DOI:10.1080/10937404.2016.1261746

C. Miller, S. Rayalam

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引用次数: 19

Abstract

ABSTRACT People living in regions of low socioeconomic status are thought to be prone to higher exposures to environmental pollutants, poor nutrition, and numerous preventable diseases and infections. Poverty correlates with pollution and malnutrition; however, limited studies examined their interrelationship. The well-studied, deleterious health effects attributed to environmental pollutants and poor nutrition may act in combination with produce more severe adverse health outcomes than any one factor alone. Deficiencies in specific nutrients render the body more susceptible to injury which may influence the pathways that serve as the mechanistic responses to ambient air pollutants. This review (1) explores specific micronutrients that are of global concern, (2) explains how these nutrients may impact the body’s response to ambient air pollution, and (3) provides guidance on designing animal models of nutritional deficiency. It is likely that those individuals who reside in regions of high ambient air pollution are similarly malnourished. Therefore, it is important that research identifies specific nutrients of concern and their impact in identified regions of high ambient air pollution.

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微量营养素在对环境空气污染物的反应中的作用:潜在的机制和研究设计建议

生活在低社会经济地位地区的人们被认为更容易暴露于环境污染物、营养不良和许多可预防的疾病和感染。贫穷与污染和营养不良有关;然而，有限的研究调查了它们之间的相互关系。环境污染物和营养不良对健康造成的有害影响已得到充分研究，它们结合起来可能比任何一个单独因素产生更严重的不良健康后果。特定营养素的缺乏使身体更容易受到伤害，这可能影响作为对环境空气污染物的机械反应的途径。本综述(1)探讨了全球关注的特定微量营养素，(2)解释了这些营养素如何影响人体对环境空气污染的反应，(3)为设计营养缺乏的动物模型提供了指导。居住在环境空气污染严重地区的人很可能也同样营养不良。因此，重要的是研究确定特定的关注营养物质及其在确定的高环境空气污染区域的影响。

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来源期刊

Journal of Toxicology and Environmental Health-Part B-Critical Reviews 环境科学-毒理学

CiteScore

13.80

自引率

6.90%

发文量

审稿时长

>24 weeks

期刊介绍： "Journal of Toxicology and Environmental Health: Part B - Critical Reviews" is an academic journal published by Taylor & Francis, focusing on the critical examination of research in the areas of environmental exposure and population health. With an ISSN identifier of 1093-7404, this journal has established itself as a significant source of scholarly content in the field of toxicology and environmental health. Since its inception, the journal has published over 424 articles that have garnered 35,097 citations, reflecting its impact and relevance in the scientific community. Known for its comprehensive reviews, the journal also goes by the names "Critical Reviews" and "Journal of Toxicology & Environmental Health, Part B, Critical Reviews." The journal's mission is to provide a platform for in-depth analysis and critical discussion of the latest findings in toxicology, environmental health, and related disciplines. By doing so, it contributes to the advancement of knowledge and understanding of the complex interactions between environmental factors and human health, aiding in the development of strategies to protect and improve public health.