Significant association of HLA-Cw and HLA-DRB1 alleles with recurrent aphthous stomatitis

Asian Journal of Oral and Maxillofacial Surgery Pub Date : 2011-03-01 DOI:10.1016/j.ajoms.2010.10.003

Yasuaki Sakata, Shoichiro Kokabu, Junya Nojima, Norimichi Nakamoto, Yosuke Fukushima, Tsuyoshi Sato, Tetsuya Yoda

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引用次数: 4

Abstract

Objectives

The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leukocyte antigen (HLA) class 1 and class 2 alleles.

Materials and methods

Nucleotide sequence level typing of HLA-A, -B, -Cw, and -DRB1 alleles was performed on Japanese patients with RAS and their families. The subjects that participated in this study consisted of 25 families that had at least one patient suffering from RAS.

Results

One HLA-Cw allele, Cw*0303, and three HLA-DRB1 alleles, DRB1*0401, DRB1*0803 and DRB1*1101, showed a significant positive association with RAS. No HLA-A and HLA-B alleles showed significant association with RAS.

Conclusion

The present study strongly suggests the significant positive association of HLA alleles with RAS. No HLA-A and HLA-B alleles showed significant association with RAS. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of RAS.

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HLA-Cw和HLA-DRB1等位基因与复发性口腔炎的显著相关性

目的探讨复发性口疮性口炎(RAS)与人类白细胞抗原(HLA) 1类和2类等位基因的遗传关系。材料与方法对日本RAS患者及其家属进行HLA-A、-B、-Cw和-DRB1等位基因的核苷酸序列分型。参加本研究的受试者包括25个至少有一名RAS患者的家庭。结果1个HLA-Cw等位基因Cw*0303和3个HLA-DRB1等位基因DRB1*0401、DRB1*0803和DRB1*1101与RAS呈显著正相关。HLA-A和HLA-B等位基因与RAS均无显著相关性。结论HLA等位基因与RAS有显著正相关。HLA-A和HLA-B等位基因与RAS均无显著相关性。因此，本研究提示HLA等位基因或紧密连锁位点可能参与RAS的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Asian Journal of Oral and Maxillofacial Surgery

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