Comparison of Interlukin-10, Tumor Necrosis Factor-α and Complement-3 Levels among Bangladeshi Pregnant Women with or without Hepatitis E Virus Infection

Journal of National Institute of Neurosciences Bangladesh Pub Date : 2023-01-15 DOI:10.3329/jninb.v8i2.63752

Rabeya Sultana, Niilufa Parvin, P. Deb, S. Munshi, S. Tabassum

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Abstract

Background: Several plasma proteins are proposed as biomarkers for acute HEV infected patients, but have not been validated among pregnant Bangladeshi women infected with HEV. Objective: In this present study, levels of interlukin-10 (IL-10), tumor necrosis factor α (TNF-α) and complement-3 (C3) were measured among HEV infected pregnant women and were compared with pregnant and HEV infected women. Methodology: This comparative cross-sectional study was conducted among the pregnant women who were admitted to the Department of Medicine, Department of Obstetrics & Gynecology, and Department of Hepatology of Dhaka Medical College Hospital (DMCH) and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh for 1 year period. The study population included acute HEV infected pregnant women (HEV-P), healthy pregnant women (HPC) and HEV-infected non-pregnant women (HEV-NP) of the same age group. Interlukin-10 (IL-10), Tumor necrosis factor α (TNF-α) and complement 3(C3) levels were quantified by enzyme linked immunosorbent assay (ELISA) and turbidometry, respectively. Result: A total number of 81 women were recruited for this study of which 31 cases were acute HEV infected pregnant women (HEV-P); 25 cases were healthy pregnant women (HPC) and 25 cases were HEV infected non-pregnant women (HEV-NP) of the same age group. The mean levels with SD of the C3 level showed significant difference (P; 0.05) between groups of HEV-P (67.73±38.24 mg/dl), HEV-NP (147.9±22.28 mg/dl) and HPC (182.6±17.49 mg/dl). Though plasma TNF-α did not show any significant change (P; .05) in any of the groups, the IL-10 level was elevated significantly (p; 0.05) in HEV infected pregnant patients (0.187±0.3 ng/ml) then the non-pregnant HEV patients (0.027 + .08 ng/ml) and pregnant women group (0.012±0.04 ng/ml). Conclusion: In conclusion, increased levels of C3 and IL-10 observed in HEV infected pregnant women. Journal of National Institute of Neurosciences Bangladesh, July 2022;8(2):157-161

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孟加拉国感染或未感染戊型肝炎病毒孕妇白细胞介素-10、肿瘤坏死因子-α和补体-3水平的比较

背景:一些血浆蛋白被提议作为急性HEV感染患者的生物标志物，但尚未在感染HEV的孟加拉国孕妇中得到验证。目的:本研究检测了HEV感染孕妇的白细胞介素-10 (IL-10)、肿瘤坏死因子α (TNF-α)和补体-3 (C3)水平，并与孕妇和HEV感染妇女进行了比较。方法:本比较横断面研究是在孟加拉国达卡达卡医学院医院(DMCH)和Bangabandhu Sheikh Mujib医科大学(BSMMU)内科、妇产科和肝病科住院1年的孕妇中进行的。研究人群包括同一年龄组的急性HEV感染孕妇(HEV- p)、健康孕妇(HPC)和感染HEV的非孕妇(HEV- np)。采用酶联免疫吸附法(ELISA)和浊度法分别测定各组白细胞介素-10 (IL-10)、肿瘤坏死因子α (TNF-α)和补体3(C3)水平。结果:本研究共招募了81名妇女，其中31例为急性HEV感染孕妇(HEV- p);同一年龄组健康孕妇(HPC) 25例，感染HEV的非孕妇(HEV- np) 25例。C3水平与SD的平均水平差异有统计学意义(P;HEV-P组(67.73±38.24 mg/dl)、HEV-NP组(147.9±22.28 mg/dl)和HPC组(182.6±17.49 mg/dl)之间差异无统计学意义(0.05)。血浆TNF-α无明显变化(P;0.05)， IL-10水平显著升高(p;HEV感染孕妇组(0.187±0.3 ng/ml)、非妊娠HEV组(0.027±0.08 ng/ml)、孕妇组(0.012±0.04 ng/ml)。结论:HEV感染孕妇体内C3和IL-10水平升高。孟加拉国国家神经科学研究所杂志，2022年7月;8(2):157-161

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Journal of National Institute of Neurosciences Bangladesh

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