{"title":"Future directions in antiplatelet therapy: efficacy versus safety","authors":"Nadzeya Kuzniatsova, Eduard Shantsila MD, Gregory YH Lip MD, FRCP","doi":"10.1002/fps.52","DOIUrl":null,"url":null,"abstract":"<p>An improved understanding of the underlying mechanisms of platelet activation and thrombogenesis has led to the discovery of new antiplatelet agents. Various clinical studies have investigated the effectiveness of these new agents in comparison with ‘traditional’ antiplatelet drugs. The problem with this approach is that enhanced antiplatelet activity may result in excessive bleeding complications. Consequently, the challenge is to ascertain the fine balance between optimal efficacy and safety for future antiplatelet drugs and their combinations. Copyright © 2009 John Wiley & Sons, Ltd.</p>","PeriodicalId":100566,"journal":{"name":"Future Prescriber","volume":"10 3","pages":"20-23"},"PeriodicalIF":0.0000,"publicationDate":"2009-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/fps.52","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Prescriber","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fps.52","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
An improved understanding of the underlying mechanisms of platelet activation and thrombogenesis has led to the discovery of new antiplatelet agents. Various clinical studies have investigated the effectiveness of these new agents in comparison with ‘traditional’ antiplatelet drugs. The problem with this approach is that enhanced antiplatelet activity may result in excessive bleeding complications. Consequently, the challenge is to ascertain the fine balance between optimal efficacy and safety for future antiplatelet drugs and their combinations. Copyright © 2009 John Wiley & Sons, Ltd.
抗血小板治疗的未来方向:疗效与安全性
对血小板活化和血栓形成的潜在机制的进一步了解导致了新的抗血小板药物的发现。各种临床研究已经调查了这些新药与“传统”抗血小板药物的有效性。这种方法的问题是抗血小板活性的增强可能导致过多的出血并发症。因此，挑战在于确定未来抗血小板药物及其组合的最佳疗效和安全性之间的微妙平衡。版权所有©2009 John Wiley &儿子,有限公司
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