Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils

Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie Pub Date : 2001-12-01 DOI:10.1016/S0764-4469(01)01392-0

Christophe Perrin , Jacques Bayle , Sylvie Bannwarth , Jean-François Michiels , Philippe Heudier , Jean-Claude Lefebvre , Valérie Giordanengo

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引用次数: 12

Abstract

In vitro, LSLCL is expressed by numerous myeloid, promyelocytic, and T or B lymphoblastoid cell lines. In vivo, LSLCL is strongly expressed in bone marrow and only faintly in lymphoid organs. We show here that, in bone marrow, LSLCL is detected: (i) concentrated in the cytoplasm of immature neutrophils but not in myeloblasts nor in mature neutrophils, (ii) in extracellular bone marrow fluid. Besides, numerous cDNAs, similar to LSLCL (identity of 93–99 %), are found in ‘expressed sequence tags’ databases from various origins, mostly fetal and undifferentiated tumour tissues. Since LSLCL and various closely related cDNAs are expressed at definite stages of cellular maturation processes, we hypothesize that this class of proteins could play an important role in the control of cellular differentiation.

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LSLCL是一种新的c型凝集素，其在骨髓中的表达仅限于未成熟的中性粒细胞

在体外，LSLCL在许多髓系、早幼粒细胞和T或B淋巴母细胞样细胞系中表达。在体内，LSLCL在骨髓中强烈表达，仅在淋巴器官中微弱表达。我们在这里显示，在骨髓中，LSLCL被检测到:(i)集中在未成熟中性粒细胞的细胞质中，但不在成髓细胞和成熟中性粒细胞中，(ii)在细胞外骨髓液中。此外，在来自不同来源的“表达序列标签”数据库中发现了许多类似于LSLCL(同源性93 - 99%)的cdna，主要来自胎儿和未分化的肿瘤组织。由于LSLCL和各种密切相关的cdna在细胞成熟过程的特定阶段表达，我们假设这类蛋白可能在控制细胞分化中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie

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