Assessment of antidiabetic potential of Cissampelos pareira leaf extract in streptozotocin–nicotinamide induced diabetic mice

Kuldeep Singh Yadav , Narayan Prasad Yadav , Karuna Shanker , Shiny C. Thomas , Saurabh Srivastav , Shruti Srivastava , Vineet Kumar Rai , Nidhi Mishra , Priyam Sinha
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引用次数: 15

Abstract

Objective

To validate the traditional use of Cissampelos pareira as an antidiabetic agent in streptozotocin–nicotinamide induced diabetic male mice.

Methods

Antidiabetic effect of aqueous extract of C. pareira leaves (CPAE) was evaluated at 250 mg/kg and 500 mg/kg body weight, p.o. doses in male albino mice over the period of 14 days. Random blood glucose level and body weight were observed periodically. Liver glycogen level, organ coefficient and other biochemical parameters were also determined after completion of the study.

Result

Significant (p < 0.001) changes were observed in random blood glucose levels of mice after 14 days of treatment period at 500 mg/kg CPAE treatment. Aspartate transaminase, alanine transaminase, alkaline phosphatase, total bilirubin, triglycerides and creatinine levels were significantly (p < 0.05) decreased while liver tissue glycogen and serum protein levels were significantly (p < 0.05) increased after CPAE administration. No significant changes were observed in body weight and organ coefficient.

Conclusions

The present study concluded that the aqueous extract of C. pareira at 500 mg/kg body weight was capable in reducing diabetic attritions so it might be a valuable candidate for diabetes treatment.

顺子叶提取物对链脲佐菌素-烟酰胺诱导的糖尿病小鼠的降糖作用
目的验证传统方法对链脲佐菌素-烟酰胺诱导的糖尿病雄性小鼠的降糖作用。方法以250 mg/kg和500 mg/kg体重的双伞叶水提物(CPAE)对雄性白化小鼠14 d的抗糖尿病作用进行研究。定期观察随机血糖水平和体重。研究结束后测定肝糖原水平、脏器系数等生化指标。结果显著(p <500 mg/kg CPAE治疗14 d后小鼠随机血糖水平变化0.001)。谷草转氨酶、丙氨酸转氨酶、碱性磷酸酶、总胆红素、甘油三酯和肌酐水平显著(p <0.05),肝组织糖原和血清蛋白水平显著降低(p <0.05), CPAE给药后升高。体重和脏器系数未见明显变化。结论以500 mg/kg体重的水提物可有效降低糖尿病的消耗,是一种有价值的糖尿病治疗药物。
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