The Combination Effect of Ferulic Acid and Gemcitabine on Expression of Genes Related Apoptosis and Metastasis in PC-3 Prostate Cancer Cells

Central European Journal of Biology Pub Date : 2019-02-18 DOI:10.26650/eurojbiol.2018.0003

C. Eroglu, E. Avcı, Mücahit Seçme, Y. Dodurga, H. Vural, E. Kurar

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引用次数: 4

Abstract

DOI : 10.26650/EuroJBiol.2018.0003 Objective : Prostate cancer is the second most common cause of cancer-related deaths in men. Nowadays, new treatment approaches have been tested for cancer therapy including natural compounds with low toxicity. Ferulic acid (FA) is known as an abundant phenolic compound found in various fruits and vegetables. As a potent antioxidant, the anticarcinogenic effect of FA has been demonstrated in various cancer cell lines. The objective of this study was to investigate the combined effect of FA and gemcitabine on apoptosis and metastasis in PC-3 human prostate cancer cell lines. Materials and Methods : Cell viability was determined using the XTT method after the cells were treated with gemcitabine or FA and gemcitabine. According to the results of cytotoxicity assays, PC-3 cells were treated with

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阿魏酸联合吉西他滨对PC-3前列腺癌细胞凋亡及转移相关基因表达的影响

目的:前列腺癌是男性癌症相关死亡的第二大常见原因。如今，新的治疗方法已经被测试用于癌症治疗，包括低毒性的天然化合物。阿魏酸(FA)是一种丰富的酚类化合物，存在于各种水果和蔬菜中。作为一种有效的抗氧化剂，FA的抗癌作用已在多种癌细胞系中得到证实。本研究旨在探讨FA联合吉西他滨对人前列腺癌PC-3细胞株凋亡和转移的影响。材料与方法:细胞经吉西他滨或FA +吉西他滨处理后，采用XTT法测定细胞活力。细胞毒性试验结果显示，200 μM FA + 35 μM吉西他滨联合剂量

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