Protective Effects of Sesamol on the Brains of Rats with Focal Cerebral Ischemia-Reperfusion Injury

X. Guannan, G. Xiujuan, L. Xin, Z. Yujue, L. Zhaoyong, C. Ximeng, L. Fengzhen
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Abstract

Stroke is an acute cerebrovascular event associated with brain tissue injury, representing the most common cause of death. Thrombolysis and recanalization are the principal treatment modalities for ischemic stroke. Some patients experience cerebral ischemia-reperfusion injury following treatment. A previous study established that sesamol is effective in reducing risk factors for stroke. Here, we aimed to investigate the protective effect of sesame phenol on cerebral ischemia-reperfusion injury. A total of 72 SD rats were randomly divided into a sham group, cerebral ischemia-reperfusion (MCAO) group, cerebral ischemia-reperfusion with low dose sesame phenol (MCAO+sesamol A) group and cerebral ischemia-reperfusion with high dose sesame phenol (MCAO + sesamol B) group. After cerebral ischemia had been induced for 2h and reperfusion conducted for 24h, the volume of cerebral infarction, the degree of cerebral edema and the neurological deficit scores were tested. The results showed sesamin improved the neurological deficit score in a dose-dependent manner, reduced the volume of cerebral infarction, degree of cerebral edema. Prophylactic treatment with sesame phenol provided neuroprotective effects on cerebral ischemia-reperfusion injury.
芝麻酚对局灶性脑缺血再灌注损伤大鼠脑的保护作用
中风是一种与脑组织损伤相关的急性脑血管事件,是最常见的死亡原因。溶栓和再通是缺血性脑卒中的主要治疗方式。一些患者在治疗后出现脑缺血再灌注损伤。先前的一项研究证实,芝麻酚能有效降低中风的危险因素。本实验旨在探讨芝麻酚对脑缺血再灌注损伤的保护作用。将72只SD大鼠随机分为假手术组、脑缺血再灌注(MCAO)组、低剂量芝麻酚(MCAO+芝麻酚A)脑缺血再灌注组和高剂量芝麻酚(MCAO+芝麻酚B)脑缺血再灌注组。脑缺血诱导2h,再灌注24h后,检测脑梗死体积、脑水肿程度及神经功能缺损评分。结果显示,芝麻素能以剂量依赖的方式改善神经功能缺损评分,减少脑梗死体积和脑水肿程度。芝麻酚预防性治疗对脑缺血再灌注损伤具有神经保护作用。
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