Analysis of the domestic market of 1,2,4-triazole-containing drugs

Abstract

The modern market of medicines in Ukraine has the dynamics of constant development. At the same time, the dynamics of the pharmaceutical market depend entirely on the welfare of the population. Current features of quarantine restrictions have caused a number of distortions in drug consumption. Thus, after the introduction of quarantine in March 2020, part of the population panicked, which forced them to stockpile vital goods. At this time, there was a significant increase in sales of drugs, including antiviral, antiseptic, and disinfectant activity. The dynamics of drug balances on the shelves reached +50 %. However, there was a sharp decline in consumption between June-October 2020 and April 2021 due to the full effect of quarantine restrictions and March-April 2022 due to martial law in Ukraine. Today, the rate of purchases and balances of medicines on the shelves of pharmacies exceeds the rate of growth of their sales. The aim of the work is to conduct research and provide a description of the range of the national market of domestic 1,2,4-triazole-containing drugs. Materials and methods. The following methods were used in the work: analytical, information retrieval, descriptive, and generalization. The materials of the research were literature sources that contain information on the registration of domestic 1,2,4-triazole-containing drugs in Ukraine at present. Results. The search, analysis, characterization, and generalization of domestic drugs – derivatives of 1,2,4-triazoles were carried out. It was established that the Ukrainian market was moderately saturated with 1,2,4-triazole-containing drugs of domestic production based on the study of available information and scientific research. The drugs have a fairly wide range of applications in medicine, have different mechanisms of action, belong to different pharmacotherapeutic groups, and were used in veterinary practice and the agro-industrial economy. Conclusions. Elaboration, analysis, systematization, comparison, and generalization of modern sources of information indicated a fairly high biological activity of 1,2,4-triazole derivatives, a wide range of applications, and moderate saturation of the national market with 1,2,4-triazole-containing drugs.