Survey of non-alcoholic steatohepatitis in non-diabetic Haemodialysis patients in Beni-Suef Governorate

Abstract

: Background : Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are global health issues all over the world, affecting about30% (NAFLD), and15% (CKD) of general people. Even, with absence of other risk factors such as overweight, diabetes and hypertension, there is force correlation between NAFLD and CKD. Objective: The target of our study is to detect the incidence of non-alcoholic steatohepatitis between non-diabetic hemodialysis patients by measuring Controlled Attenuation Parameter (CAP) using transient elastography (TE) (Fibroscan®). Methodology: This was a cross sectional study in Beni-Suef governorate, including 1000 hemodialysis non-diabetic ESRD patients from different hemodialysis units from all the central hospitals in Beni-Suef governorate. Results : According to CAP (dB/M) there were 503(50.3%) S0, 233(23.3%) S1, 100(10.0%) S1-S2, 67(6.7%) S2,10(1.0%) S2-S3 and 87(8.7%) S3. According to liver stiffness grades there were 508(50.8%) F0, 280(28.0%) F1, 57(5.7%) F2,95(9.5%) F3 and 60(6.0%) F4. There were 508(50.8%) F0 and 492(49.2%) F1:F4 with mean 6.14 (± 3.90SD) and range (2.0 – 19.90). Conclusions: In this study we concluded that there is a high incidence of NAFLD among non-diabetic patients on regular Hemodialysis in Beni-Suef governorate, significantly correlated with increasing degree of liver stiffness.