Butyrate in the treatment of experimental models of colitis

Digestive and Liver Disease Supplements Pub Date : 2007-09-01 DOI:10.1016/S1594-5804(08)60005-4

G. D'Argenio, G. Mazzone, N. Caporaso

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引用次数: 1

Abstract

Background

Note that butyrate is utilised by colonocytes in energy production and that deficiency of this substance is observed in the colon of patients with chronic inflammatory bowel disease.

Aims

We first assessed the efficacy of butyrate in rats with induced colitis, and since this condition represents a condition of increased risk of colonic neoplasia, we also evaluated whether butyrate treatment reduces susceptibility of the mucosa to the emergence of carcinoma in the colon of rats with experimental colitis.

Materials and methods

Colitis was induced with trinitrobenzene-sulphonic acid and colonic tumours were induced with azoxymethane.

Results

Colitis improved noticeably following treatment with butyrate and tumours emerging in colitis were significantly reduced in both size and number.

Conclusions

The results obtained suggest the need for further study of the metabolic fate of butyrate and its role in maintaining the mucosal integrity of the colon.

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丁酸盐对实验性结肠炎模型的治疗作用

背景:需要注意的是，丁酸盐被结肠细胞用于能量生产，并且在慢性炎症性肠病患者的结肠中观察到这种物质的缺乏。目的:我们首先评估了丁酸盐对实验性结肠炎大鼠的疗效，由于这种情况代表了结肠瘤变风险增加的情况，我们还评估了丁酸盐治疗是否降低了实验性结肠炎大鼠结肠粘膜对癌发生的易感性。材料与方法用三硝基苯磺酸诱导结肠炎，用偶氮甲烷诱导结肠肿瘤。结果丁酸盐治疗后结肠炎明显改善，结肠炎中出现的肿瘤大小和数量均明显减少。结论有必要进一步研究丁酸盐的代谢命运及其在维持结肠粘膜完整性中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Digestive and Liver Disease Supplements

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