Awareness, Knowledge, and Acceptance of Haematopoietic Stem Cell Transplantation for Sickle Cell Anaemia in Nigeria.

Bone Marrow Research Pub Date : 2016-01-01 Epub Date: 2016-09-27 DOI:10.1155/2016/7062630
Adewumi Adediran, Modu Baba Kagu, Tamunomieibi Wakama, Aliyu Ahmadu Babadoko, Dapus Obadiah Damulak, Sunday Ocheni, Marcus Inyama Asuquo
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Abstract

Background. Sickle cell anaemia (SCA) is an inherited condition whose clinical manifestations arise from the tendency of haemoglobin to polymerize and deform red blood cells into characteristic sickle shape. Allogeneic bone marrow transplantation offers a cure. The aim of this study was to determine the level of awareness, knowledge, and acceptance of this beneficial procedure in Nigeria. Materials and Methods. This multicentre cross-sectional study was conducted in 7 tertiary hospitals in Nigeria in 2015. Approval was obtained from each institution's research and ethics committee. A pretested structured questionnaire was administered to respondents aged 18 years and above and to the parents or guardians of those below 18 years of age. Results. There were 265 respondents comprising 120 males and 145 females. One hundred and seventy-one (64.5%) respondents were aware of BMT for the treatment of SCA. About 67.8% (116 of 171) of those who were aware believed SCA can be cured with BMT (p = 0.001) and 49.7% (85 of 171) of the respondents accepted BMT (p = 0.001). Conclusion. Awareness of BMT in Nigeria is low when compared with reports from developed countries. The knowledge is poor and acceptance is low. With adequate information, improved education, and psychological support, more Nigerians will embrace BMT.

尼日利亚对造血干细胞移植治疗镰状细胞性贫血的认识、知识和接受程度。
背景。镰状细胞性贫血(SCA)是一种遗传性疾病,其临床表现是由于血红蛋白容易聚合,使红细胞变形为镰状。异体骨髓移植可以治愈这种疾病。本研究旨在确定尼日利亚对这一有益手术的认识、了解和接受程度。材料和方法。这项多中心横断面研究于 2015 年在尼日利亚的 7 家三级医院进行。研究获得了各机构研究和伦理委员会的批准。对 18 岁及以上的受访者和 18 岁以下受访者的父母或监护人进行了预先测试的结构式问卷调查。结果。共有 265 名受访者,其中男性 120 人,女性 145 人。171名受访者(64.5%)知道 BMT 可用于治疗 SCA。约 67.8%(171 人中的 116 人)的受访者认为 BMT 可以治愈 SCA(p = 0.001),49.7%(171 人中的 85 人)的受访者接受 BMT(p = 0.001)。结论。与发达国家的报告相比,尼日利亚对 BMT 的认知度较低。知识水平低,接受度也低。如果有足够的信息、更好的教育和心理支持,将会有更多的尼日利亚人接受 BMT。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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