The Relationship/Association of Triglyceride and Severity of Coronary Artery Disease: Is Triglyceride Really a Risk Factor for Coronary Artery Disease?

University Heart Journal Pub Date : 2022-11-08 DOI:10.3329/uhj.v18i2.62732

K. K. Karmoker, Khandaker Aisha Siddika, Mohammad Walidur Rahman, Bijoy Datta, M. B. Rashid, Golam Rahman Mallick, Niranjan Kumar Sana

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Abstract

Worldwide, the major cause of mortality and morbidity is coronary artery disease (CAD). In the pathogenesis and progression of atherosclerosis, lipid and its metabolites play an important role. The aim of the study was to find out the association of triglyceride (TG) level on the severity of coronary artery disease (CAD) in patients with ischemic heart disease (IHD). In this cross-sectional study, 431 patients with ischemic heart disease were enrolled after taking informed written consent. TG level were categorized into normal (< 150 mg/dl), borderline (150-199 mg/dl) and high (³200 mg/dl). Patients with ischemic heart disease (IHD) were stratified according to TG level. Severity of CAD was assessed by the Gensini score. Most of the patients (33.4%) belonged to the age group 51–60 years. The mean age was 51.31±10.30 years. The majority (74.5%) of patients were male. Among risk factors, 205 (47.6%) patients were smokers, followed by hypertension 190 (44.1%) and diabetes mellitus 175 (40.5%). The association of TG with the whole spectrum of IHD was found statistically significant (p < 0.05). Moderate to severe CAD was found to be higher in the high TG level group compared with the other groups and was statistically significant. University Heart Journal 2022; 18(2): 101-105

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甘油三酯与冠状动脉疾病严重程度的关系/关联:甘油三酯真的是冠状动脉疾病的危险因素吗?

在世界范围内，导致死亡和发病的主要原因是冠状动脉疾病(CAD)。在动脉粥样硬化的发病和发展过程中，脂质及其代谢产物起着重要作用。本研究旨在探讨甘油三酯(TG)水平与缺血性心脏病(IHD)患者冠状动脉疾病(CAD)严重程度的关系。在这项横断面研究中，431例缺血性心脏病患者在获得知情书面同意后入组。TG水平分为正常(< 150 mg/dl)、临界(150 ~ 199 mg/dl)和高(3 ~ 200 mg/dl)。根据TG水平对缺血性心脏病(IHD)患者进行分层。通过Gensini评分评估CAD的严重程度。51 ~ 60岁年龄组占33.4%。平均年龄51.31±10.30岁。男性占74.5%。吸烟205例(47.6%)，高血压190例(44.1%)，糖尿病175例(40.5%)。TG与IHD全谱相关性有统计学意义(p < 0.05)。高TG组中至重度冠心病发生率高于其他组，差异有统计学意义。大学心脏杂志2022;18 (2): 101 - 105

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University Heart Journal

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