Integrative analysis of TRPV family to prognosis and immune infiltration in renal clear cell carcinoma

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Channels Pub Date : 2022-04-07 DOI:10.1080/19336950.2022.2058733

Zixuan Gong, Jiaheng Xie, Liang Chen, Q. Tang, Yiming Hu, A. Xu, Zengjun Wang

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引用次数: 4

Abstract

ABSTRACT The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is closely associated with immune infiltration. However, the expression and prognosis of TRPV family and tumor-infiltrating immune cells in ccRCC are obscure. This study aimed to explore the prognostic and therapeutic value of the TRPV family expression in ccRCC from the perspective of bioinformatics. We analyzed the transcriptome and clinical data of kidney renal clear cell carcinoma (KIRC) from The Cancer Genome Atlas (TCGA) database. A clustering analysis and immune infiltration analysis were conducted to investigate the influence of the TRPV family genes on ccRCC. Our study found that the TRPV family is an excellent prognostic stratification for ccRCC. Among them, TRPV3 is the most significant prognostic marker of ccRCC. In addition, we performed a drug sensitivity analysis to identify the drugs with the strongest association with TRPV3. As a result, the TRPV family, particularly TRPV3, can act as a prognostic biomarker in ccRCC to determine prognosis and levels of immune infiltration.

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肾透明细胞癌TRPV家族与预后及免疫浸润的综合分析

瞬时受体电位香草蛋白(transient receptor potential vanilloid, TRPV)家族已被初步发现在多种癌症中发挥重要作用，包括透明细胞肾细胞癌(clear cell renal cell carcinoma, ccRCC)，其与免疫浸润密切相关。然而，TRPV家族和肿瘤浸润性免疫细胞在ccRCC中的表达和预后尚不清楚。本研究旨在从生物信息学角度探讨TRPV家族表达在ccRCC中的预后和治疗价值。我们分析了来自癌症基因组图谱(TCGA)数据库的肾透明细胞癌(KIRC)的转录组和临床数据。采用聚类分析和免疫浸润分析探讨TRPV家族基因对ccRCC的影响。我们的研究发现TRPV家族是ccRCC的一个很好的预后分层。其中，TRPV3是ccRCC最重要的预后指标。此外，我们还进行了药物敏感性分析，以确定与TRPV3相关性最强的药物。因此，TRPV家族，特别是TRPV3，可以作为ccRCC的预后生物标志物，以确定预后和免疫浸润水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Channels 生物-生化与分子生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Channels is an open access journal for all aspects of ion channel research. The journal publishes high quality papers that shed new light on ion channel and ion transporter/exchanger function, structure, biophysics, pharmacology, and regulation in health and disease. Channels welcomes interdisciplinary approaches that address ion channel physiology in areas such as neuroscience, cardiovascular sciences, cancer research, endocrinology, and gastroenterology. Our aim is to foster communication among the ion channel and transporter communities and facilitate the advancement of the field.