Biological activity evaluation of three Hypericum species wild growing in Sivas province of Turkey

Abstract

The objective of the study to evaluate methanolic extracts of aerial parts of three Hypericum species: Hypericum perforatum, Hypericum thymbrifolium and Hypericum thymopsis for their in vitro antioxidant, anti-Trichomonas vaginalis activity, antimicrobial and cytotoxic activity. The antioxidant activity of methanol extract was tested with DPPH, iron chelating, total phenol and total flavonoid content assays. Cytotoxicity and apoptosis were evaluated on MCF-7 breast cancer and PC3 prostate cancer cell line. Antimicrobial activity were evaluated by a microdilution method on five microorganisms. The obtained results of the present study revealed that methanol extract of H. thymbrifolium, H. perforatum and H. thymopsis have significant antioxidant, cytotoxic activity. The results are provided the basic research data for further phytochemical and biological activity guided investigation on thes species for identicate and isolation of potential drug active compounds.