ASPECTS OF HIV-ASSOCIATED CARDIOVASCULAR PATHOLOGY AGAINST THE BACKGROUND OF ANTIRETROVIRAL THERAPY

Abstract

Annotation. The identification of cardiological pathology in patients at various stages of HIV infection is relevant due to the data available in the scientific medical literature on the negative impact of this infection on the cardiovascular system. The published article presents the results of a cardiological examination of 60 patients in the third (20 patients) and fourth (40 patients) stages of HIV infection. Cardiological pathology was detected in 22 (37%) HIV infected patients, 5 of them with stage 3 and 17 with stage 4 of the disease. Infectious endocarditis with tricuspid valve lesion was diagnosed more often than other types of cardiological pathology in 20 patients (91%). Comparison of the results obtained with the use of antiretroviral therapy (ART) showed that among patients who did not receive ART for the entire period of the disease, pathology was detected in 68.4% of cases; among patients with late initiation of ART or lack of adherence, it was detected in 58% of cases; in those who received ART in a timely and regular manner, cardiological pathology was found in five times less often in 11.8%. This suggests that ART has a significant inhibitory effect on the development of cardiovascular pathology in HIV infection.