Effects of oral prednisolone and fluticasone nasal spray in the management of chronic rhinosinusitis with polyposis: A prospective observational study

IF 0.6 Q3 Medicine

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2023-05-15 DOI:10.18231/j.ijashnb.2023.003

S. Jonnalagadda, A. Jaiswal, N. Sharma, Prachi Mene

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引用次数: 0

Abstract

To study the effects of combination therapy with oral prednisolone and topical fluticasone propionate nasal spray in patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP). To study the improvement in symptom scores, Endoscopic and CT scores before and after treatment with combination therapy.This prospective observational study was conducted on 50 patients attending the Outpatient Department of Otorhinolaryngology, J.L.N Hospital and Research Centre, Bhilai (Chhattisgarh), India over a period of 6 months from February 2020 to July 2020. Patients with symptoms of CRSwNP persisting for more than 12 weeks were thoroughly examined clinically along with Nasal endoscopy and Computed Tomography scan of Nose and Paranasal sinuses (CT PNS) and pre-treatment Visual Analog Scale (VAS), Lund & Mackay Scores for Endoscopic and CT findings were noted. Patients were treated with combination therapy of oral prednisolone and fluticasone propionate nasal spray and post treatment scores were noted using similar scales during the follow up visits and the results were statistically analysed.Total mean age of patients suffering from CRSwNP in our study was 47.3 ± 12.58. Males were affected more by CRSwNP than females (76% vs 24%). At the end of 3 months from baseline 48 patients (96%) showed a reduction in nasal discharge, 47 patients (94%) showed a reduction in nasal obstruction, 25 patients (50%) showed improvement in facial pain and 17 patients (34%) showed improvement in hyposmia. Overall post treatment Visual Analog Symptom (VAS) score improved in 42 patients (84%), Nasal endoscopy (Lund - Mackay scoring) improved in 43 patients (86%) and Radiological CT PNS & Nose (Lund - Mackay Scoring) improved in 33 patients (66%).We found that combined therapy with oral prednisolone and fluticasone propionate nasal spray for 3 weeks is very effective in reducing the symptoms of chronic rhinosinusitis along with decrease in nasal secretions, edema and polyp size.

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口服泼尼松龙和氟替卡松鼻喷雾剂治疗慢性鼻窦炎伴息肉病的疗效:一项前瞻性观察研究

目的:探讨口服强的松龙与外用丙酸氟替卡松鼻喷雾剂联合治疗慢性鼻窦炎伴鼻息肉病(CRSwNP)的疗效。探讨联合治疗前后症状评分、内镜及CT评分的改善情况。这项前瞻性观察研究是在2020年2月至2020年7月的6个月期间，对印度比莱(恰蒂斯加尔邦)J.L.N医院和研究中心耳鼻咽喉科门诊的50名患者进行的。对症状持续超过12周的CRSwNP患者进行彻底的临床检查，并进行鼻内窥镜检查和鼻及鼻窦炎CT扫描(CT PNS)和治疗前视觉模拟评分(VAS)，记录内窥镜和CT表现的Lund & Mackay评分。患者接受口服强的松龙和丙酸氟替卡松鼻喷雾剂联合治疗，随访时采用类似量表记录治疗后评分，并对结果进行统计分析。本研究中CRSwNP患者的总平均年龄为47.3±12.58岁。男性比女性更容易受到CRSwNP的影响(76%对24%)。3个月后，48例(96%)患者鼻排出物减少，47例(94%)患者鼻塞减少，25例(50%)患者面部疼痛改善，17例(34%)患者低氧症状改善。总体治疗后视觉模拟症状(VAS)评分改善42例(84%)，鼻内窥镜检查(Lund - Mackay评分)改善43例(86%)，放射CT PNS和鼻(Lund - Mackay评分)改善33例(66%)。我们发现口服强的松龙和丙酸氟替卡松鼻喷雾剂联合治疗3周对减轻慢性鼻窦炎的症状以及减少鼻分泌物、水肿和息肉大小非常有效。

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.90

自引率

0.00%

发文量

226

审稿时长

3 months

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.