Synthesis & characterization of iron-carboxylate nanoscale metal organic frameworks for drug delivery

Abstract

MIL-101-Fe (Materials of Institute Lavoisier) nanoscale-metal organic frameworks (NMOFs) were synthesized by solvothermal method with constant heating at 200°C in silicon oil bath. The as prepared MIL-101-Fe nanoparticles are observed to have particle size in the range of 200-210 nm with multiple shape morphology. Further as prepared MIL-101-Fe are functionalized by incorporating amine group into the framework. Drug loaded NMOF were coated with silica to control the rate of release of drug by avoiding rapid degradation of the NMOF in alkaline pH of PBS buffer. The drug release profile showed that the drug from MIL-101-Fe is released completely in ~32 hrs while for SiO2@Drug@ MIL-101-Fe is extended upto 75 hrs. Silica coated SiO2@Drug@ NH2-MIL-101-Fe particles had adequate stability for drug delivery application.