Correlation between Expressions of Estrogen Receptor, Thymidylate Synthase and CAF Regime Sensibility in Breast Carcinoma

Abstract

To study the efficacy of one regimes of commonly used chemotherapy( cyclophosphamide + adriamycin+ 5-fluorouracil, CAF) and its relationship with estrogen receptor(ER), thymidylate synthase (TS) for breast carcinoma. Methods The inhibition rates of CAF with primary cell culture were observed by MTT method in 111 cases of breast carcinoma. The expressions of TS, ER in 111 cases of breast cancer and 38 cases of adenofibroma were examined by streptavidin-perosidase immunohistochemistry method. Results Positive rates of TS and ER were higher in breast carcinoma than that in adenofibroma. Expression of ER was related to histological type in breast carcinoma (P<;0.05). Expressions rates of TS and ER were related to lymph node metastasis (P<;0.05). The sensitive rate of CAF chemotherapy protocols was 44.1%. There was relationship between expressions of TS, ER and sensitive rate of CAF chemotherapy protocols. Conclusion: The overexpressions of TS, ER may play an important role in the carcinogenesis of breast cancer. Detection of TS, ER expressions in breast carcinoma may direct to choose CAF chemotherapy.