Skin Beautification with an ImmunatuRNA® Complex: A Natural Complex Based on Yeast RNA and Marine Derivatives on the Human Skin Immunity and Microbiome Composition

IF 1.1 Q4 ALLERGY
V. Neymann
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引用次数: 0

Abstract

The skin is the largest organ of human body implicated in vital physiological and immunological processes, including protection against injury, infections, and environmental exposures. Nevertheless, a number of negative external and internal factors, including increased pollution along with modern lifestyle can significantly influence on the skin immunity, promote aging and reduce regenerative capabilities. Cosmetic formulations based on natural ingredients, including plant and marine/algae extracts, and microbial-derived bio-actives may help to maintain healthy skin condition and protect its beautiful appearance. The ImmunatuRNA®* (*The trademark ImmunatuRNA® is a registered trademark in the European Union EUTM 018365297 and Great Britain UK00003630172. Any reference to the registration of the ImmunatuRNA® trademark applies to the designated territories), a signature complex (VRFD SA/VERDILAB Switzerland) based on the Natural RNA molecules obtained from yeasts, with added marine exopolysaccharides and natural hyaluronic acid with potential benefits for antibacterial and antiradical defense and maintaining skin detox homeostasis. Therefore, the main aim of this study is to experimentally assess the ImmunatuRNA® complex capabilities to enhance natural skin antioxidant defenses and protection against oxidative stress, by using human fibroblast cell culture. Additionally, this study will investigate the effects of the skincare products with added ImmunatuRNA® complex on the skin microbiome composition in the group of healthy adults with various skin types. The results obtained from the in vitro studies consistently demonstrated that treatment with an ImmunatuRNA® complex protects human fibroblasts against exposure to pro-oxidants, while at the same time enhances anti-oxidative defenses of these cells, demonstrated as reduced formation of free radicals and upregulation of SIRT-1 protein. Furthermore, the cosmetic intervention carried on the group of 10 healthy human volunteers with different skin types (oily, dry, combined, normal) aged between 23 and 65 years old demonstrated that using interchangeably of two cosmetic products-a Natural Moisturizer Probiotic Cream and Natural Detox Replenishing Face Mask containing the ImmunatuRNA® complex, for 4-weeks led to favorable changes in the composition of skin microbiome observed as a reduction of relative abundance of adverse microorganisms, previously linked to the skin inflammation and infections, such as Citrobacter koseri, Bacillus spp., Enterococcus spp., Alcaligenes spp., Pantoea spp. and Staphylococcus aureus. Based on following results, the use of skincare products containing the ImmunatuRNA® complex can help maintain a healthy skin microbiome while possibly preventing against infections and negative environmental exposures, in particularly against oxidative stress in healthy adults with all types of skin with age range 23-65 years old.
用ImmunatuRNA®复合物美化皮肤:一种基于酵母RNA和海洋衍生物的天然复合物,对人体皮肤免疫和微生物组组成有影响
皮肤是人体最大的器官,参与重要的生理和免疫过程,包括防止损伤、感染和环境暴露。然而,一些负面的外部和内部因素,包括污染加剧和现代生活方式,会显著影响皮肤免疫力,促进衰老,降低再生能力。以天然成分为基础的化妆品配方,包括植物和海洋/藻类提取物,以及微生物衍生的生物活性物质,可能有助于保持健康的皮肤状况,保护其美丽的外观。ImmunatuRNA®* (* ImmunatuRNA®商标是欧盟EUTM 018365297和英国UK00003630172的注册商标。任何有关ImmunatuRNA®商标注册的参考资料均适用于指定地区),这是一种基于从酵母中获得的天然RNA分子的签名复合物(VRFD SA/VERDILAB瑞士),添加了海洋外多糖和天然透明质酸,具有抗菌和抗自由基防御以及维持皮肤排毒稳态的潜在益处。因此,本研究的主要目的是通过实验评估ImmunatuRNA®复合物增强天然皮肤抗氧化防御和氧化应激保护的能力,通过人成纤维细胞培养。此外,本研究将调查添加ImmunatuRNA®复合物的护肤品对不同皮肤类型的健康成年人皮肤微生物组组成的影响。从体外研究中获得的结果一致表明,用ImmunatuRNA®复合物治疗可以保护人成纤维细胞免受促氧化剂的影响,同时增强这些细胞的抗氧化防御能力,表现为自由基的形成减少和SIRT-1蛋白的上调。此外,对年龄在23至65岁之间的10名不同皮肤类型(油性,干性,混合性,正常)的健康人类志愿者进行的化妆品干预表明,交替使用两种化妆品-天然保湿益生菌霜和含有ImmunatuRNA®复合物的天然排毒补充面膜,4周后,皮肤微生物组的组成发生了有利的变化,观察到先前与皮肤炎症和感染有关的有害微生物的相对丰度减少,如柠檬酸杆菌、芽孢杆菌、肠球菌、碱性菌、泛菌和金黄色葡萄球菌。基于以下结果,使用含有ImmunatuRNA®复合物的护肤品可以帮助维持健康的皮肤微生物群,同时可能预防感染和负面环境暴露,特别是年龄在23-65岁之间的所有类型皮肤的健康成年人的氧化应激。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.60
自引率
10.00%
发文量
69
审稿时长
12 weeks
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