Prognostic Role of Neutrophil to Lymphocyte Ratio in Allergic Rhinitis: A Systematic Review and Meta-analysis.

IF 3.1 3区物理与天体物理 Q2 PHYSICS, APPLIED

Journal of Physics D: Applied Physics Pub Date : 2024-02-01 Epub Date: 2023-09-01 DOI:10.1007/s12070-023-04148-8

Monireh Khanzadeh, Sima Foroughi Nematollahi, Mitra Shavakhi, Arshin Ghaedi, Amirhossein Mallahi, Aida Bazrgar, Shokoufeh Khanzadeh

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引用次数: 0

Abstract

One of the crucial triggers of allergic diseases is an inflammatory reaction and neutrophil to lymphocyte ratio (NLR) is one of the systemic inflammation biomarkers. Our review aimed to evaluate role of NLR in predicting severity and comorbidities of allergic rhinitis (AR). We systematically searched Scopus, Web of Science, and PubMed to find relevant studies. Standardized mean difference (SMD) with a 95% confidence interval (CI) was reported. Due to the high levels of heterogeneity, the random-effects model was used to generate pooled effects. Eleven articles were included in the systematic review, among which ten were included in meta-analysis including 1122 healthy controls and 1423 patients with AR. We found that patients with AR had a significantly higher level of NLR than healthy controls (SMD = 0.19, 95%CI = 0.03-0.36, P = 0.03). In addition, patients with moderate to severe AR had significantly higher levels of NLR compared to those with mild AR (SMD = 0.41, 95%CI = 0.20-0.63, P < 0.001). Interestingly, it was found that NLR could associate with some comorbidities of AR, like asthma. Our results confirmed that NLR could assist clinicians in predicting the severity and comorbidities of AR.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04148-8.

查看原文本刊更多论文

中性粒细胞与淋巴细胞比率在过敏性鼻炎中的预后作用：系统回顾与元分析》。

过敏性疾病的关键诱因之一是炎症反应，而中性粒细胞与淋巴细胞比值（NLR）是全身炎症生物标志物之一。我们的综述旨在评估 NLR 在预测过敏性鼻炎（AR）的严重程度和合并症方面的作用。我们系统地检索了 Scopus、Web of Science 和 PubMed，以查找相关研究。报告了标准化平均差（SMD）和 95% 置信区间（CI）。由于异质性较高，因此采用随机效应模型来产生汇总效应。11篇文章被纳入系统综述，其中10篇被纳入荟萃分析，包括1122名健康对照者和1423名AR患者。我们发现，AR 患者的 NLR 水平明显高于健康对照组（SMD = 0.19，95%CI = 0.03-0.36，P = 0.03）。此外，与轻度AR患者相比，中重度AR患者的NLR水平明显更高（SMD = 0.41, 95%CI = 0.20-0.63, P = 0.03）：在线版本包含补充材料，可查阅 10.1007/s12070-023-04148-8。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Physics D: Applied Physics 物理-物理：应用

CiteScore

6.80

自引率

8.80%

发文量

835

审稿时长

2.1 months

期刊介绍： This journal is concerned with all aspects of applied physics research, from biophysics, magnetism, plasmas and semiconductors to the structure and properties of matter.